Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees

B. K. Chaffee, Amanda P. Beck, M. A. Owston, S. Kumar, W. B. Baze, E. R. Magden, E. J. Dick, M. Lammey, C. R. Abee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Chimpanzees (Pan troglodytes) have served as an important model for studies of reproductive diseases and aging-related disorders in humans. However, limited information is available about spontaneously occurring reproductive tract lesions in aging chimpanzees. In this article, the authors present histopathologic descriptions of lesions identified in the reproductive tract, including the mammary gland, of 33 female and 34 male aged chimpanzees from 3 captive populations. The most common findings in female chimpanzees were ovarian atrophy, uterine leiomyoma, adenomyosis, and endometrial atrophy. The most common findings in male chimpanzees were seminiferous tubule degeneration and lymphocytic infiltrates in the prostate gland. Other less common lesions included an ovarian granulosa cell tumor, cystic endometrial hyperplasia, an endometrial polyp, uterine artery hypertrophy and mineralization, atrophic vaginitis, mammary gland inflammation, prostatic epithelial hyperplasia, dilated seminal vesicles, a sperm granuloma, and lymphocytic infiltrates in the epididymis. The findings in this study closely mimic changes described in the reproductive tract of aged humans, with the exception of a lack of malignant changes observed in the mammary gland and prostate gland.

Original languageEnglish (US)
Pages (from-to)425-435
Number of pages11
JournalVeterinary Pathology
Volume53
Issue number2
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Fingerprint

Pan troglodytes
lesions (animal)
Human Mammary Glands
mammary glands
prostate gland
atrophy
hyperplasia
Atrophy
Atrophic Vaginitis
Prostate
vaginitis
Adenomyosis
Granulosa Cell Tumor
Endometrial Hyperplasia
Uterine Artery
reproductive disorders
Seminiferous Tubules
seminiferous tubules
seminal vesicles
Seminal Vesicles

Keywords

  • biological aging
  • chimpanzee
  • female
  • genital organs
  • genital organs
  • leiomyoma
  • male
  • mammary glands
  • pathology
  • uterine

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Chaffee, B. K., Beck, A. P., Owston, M. A., Kumar, S., Baze, W. B., Magden, E. R., ... Abee, C. R. (2016). Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees. Veterinary Pathology, 53(2), 425-435. https://doi.org/10.1177/0300985815620654

Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees. / Chaffee, B. K.; Beck, Amanda P.; Owston, M. A.; Kumar, S.; Baze, W. B.; Magden, E. R.; Dick, E. J.; Lammey, M.; Abee, C. R.

In: Veterinary Pathology, Vol. 53, No. 2, 01.03.2016, p. 425-435.

Research output: Contribution to journalArticle

Chaffee, BK, Beck, AP, Owston, MA, Kumar, S, Baze, WB, Magden, ER, Dick, EJ, Lammey, M & Abee, CR 2016, 'Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees', Veterinary Pathology, vol. 53, no. 2, pp. 425-435. https://doi.org/10.1177/0300985815620654
Chaffee, B. K. ; Beck, Amanda P. ; Owston, M. A. ; Kumar, S. ; Baze, W. B. ; Magden, E. R. ; Dick, E. J. ; Lammey, M. ; Abee, C. R. / Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees. In: Veterinary Pathology. 2016 ; Vol. 53, No. 2. pp. 425-435.
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