Spontaneous fungal peritonitis (Candida glabrata) in a patient with cirrhosis

Satheesh Nair, K. Shiva Kumar, Pavan Sachan, Marilou Corpuz

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We report a case of spontaneous fungal peritonitis in a patient with cirrhosis. A 70-year-old woman with cirrhosis secondary to autoimmune hepatitis was admitted with fever and abdominal distention. Paracentesis revealed neutrocytosis, and despite appropriate antibacterial coverage, no clinical improvement was noted and the ascitic fluid white cell count increased on repeat paracentesis. Two consecutive ascitic fluid cultures grew Candida glabrata, and antifungal therapy with amphotericin was initiated, pending sensitivity of the isolate. Because of worsening renal function, amphotericin was discontinued and itraconazole was started, as sensitivity of the isolate was then available. Antifungal therapy resulted in resolution of ascitic fluid neutrocytosis and culture negativity. However, the patient's renal function continued to deteriorate, necessitating hemodialysis. Despite multiple courses of antibiotics, she died of fulminant sepsis and multiorgan failure.

Original languageEnglish (US)
Pages (from-to)362-364
Number of pages3
JournalJournal of clinical gastroenterology
Volume32
Issue number4
DOIs
StatePublished - Apr 2 2001
Externally publishedYes

Keywords

  • Candida glabrata
  • Spontaneous fungal peritonitis

ASJC Scopus subject areas

  • Gastroenterology

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