Spontaneous fungal peritonitis (Candida glabrata) in a patient with cirrhosis

Satheesh Nair, K. Shiva Kumar, Pavan Sachan, Marilou Corpuz

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We report a case of spontaneous fungal peritonitis in a patient with cirrhosis. A 70-year-old woman with cirrhosis secondary to autoimmune hepatitis was admitted with fever and abdominal distention. Paracentesis revealed neutrocytosis, and despite appropriate antibacterial coverage, no clinical improvement was noted and the ascitic fluid white cell count increased on repeat paracentesis. Two consecutive ascitic fluid cultures grew Candida glabrata, and antifungal therapy with amphotericin was initiated, pending sensitivity of the isolate. Because of worsening renal function, amphotericin was discontinued and itraconazole was started, as sensitivity of the isolate was then available. Antifungal therapy resulted in resolution of ascitic fluid neutrocytosis and culture negativity. However, the patient's renal function continued to deteriorate, necessitating hemodialysis. Despite multiple courses of antibiotics, she died of fulminant sepsis and multiorgan failure.

Original languageEnglish (US)
Pages (from-to)362-364
Number of pages3
JournalJournal of Clinical Gastroenterology
Volume32
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Candida glabrata
Ascitic Fluid
Peritonitis
Paracentesis
Fibrosis
Amphotericin B
Kidney
Autoimmune Hepatitis
Itraconazole
Renal Dialysis
Sepsis
Fever
Cell Count
Anti-Bacterial Agents
Therapeutics

Keywords

  • Candida glabrata
  • Spontaneous fungal peritonitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Spontaneous fungal peritonitis (Candida glabrata) in a patient with cirrhosis. / Nair, Satheesh; Kumar, K. Shiva; Sachan, Pavan; Corpuz, Marilou.

In: Journal of Clinical Gastroenterology, Vol. 32, No. 4, 2001, p. 362-364.

Research output: Contribution to journalArticle

Nair, Satheesh ; Kumar, K. Shiva ; Sachan, Pavan ; Corpuz, Marilou. / Spontaneous fungal peritonitis (Candida glabrata) in a patient with cirrhosis. In: Journal of Clinical Gastroenterology. 2001 ; Vol. 32, No. 4. pp. 362-364.
@article{1e06a043329c452ca168b741dd5ecc05,
title = "Spontaneous fungal peritonitis (Candida glabrata) in a patient with cirrhosis",
abstract = "We report a case of spontaneous fungal peritonitis in a patient with cirrhosis. A 70-year-old woman with cirrhosis secondary to autoimmune hepatitis was admitted with fever and abdominal distention. Paracentesis revealed neutrocytosis, and despite appropriate antibacterial coverage, no clinical improvement was noted and the ascitic fluid white cell count increased on repeat paracentesis. Two consecutive ascitic fluid cultures grew Candida glabrata, and antifungal therapy with amphotericin was initiated, pending sensitivity of the isolate. Because of worsening renal function, amphotericin was discontinued and itraconazole was started, as sensitivity of the isolate was then available. Antifungal therapy resulted in resolution of ascitic fluid neutrocytosis and culture negativity. However, the patient's renal function continued to deteriorate, necessitating hemodialysis. Despite multiple courses of antibiotics, she died of fulminant sepsis and multiorgan failure.",
keywords = "Candida glabrata, Spontaneous fungal peritonitis",
author = "Satheesh Nair and Kumar, {K. Shiva} and Pavan Sachan and Marilou Corpuz",
year = "2001",
doi = "10.1097/00004836-200104000-00020",
language = "English (US)",
volume = "32",
pages = "362--364",
journal = "Journal of Clinical Gastroenterology",
issn = "0192-0790",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Spontaneous fungal peritonitis (Candida glabrata) in a patient with cirrhosis

AU - Nair, Satheesh

AU - Kumar, K. Shiva

AU - Sachan, Pavan

AU - Corpuz, Marilou

PY - 2001

Y1 - 2001

N2 - We report a case of spontaneous fungal peritonitis in a patient with cirrhosis. A 70-year-old woman with cirrhosis secondary to autoimmune hepatitis was admitted with fever and abdominal distention. Paracentesis revealed neutrocytosis, and despite appropriate antibacterial coverage, no clinical improvement was noted and the ascitic fluid white cell count increased on repeat paracentesis. Two consecutive ascitic fluid cultures grew Candida glabrata, and antifungal therapy with amphotericin was initiated, pending sensitivity of the isolate. Because of worsening renal function, amphotericin was discontinued and itraconazole was started, as sensitivity of the isolate was then available. Antifungal therapy resulted in resolution of ascitic fluid neutrocytosis and culture negativity. However, the patient's renal function continued to deteriorate, necessitating hemodialysis. Despite multiple courses of antibiotics, she died of fulminant sepsis and multiorgan failure.

AB - We report a case of spontaneous fungal peritonitis in a patient with cirrhosis. A 70-year-old woman with cirrhosis secondary to autoimmune hepatitis was admitted with fever and abdominal distention. Paracentesis revealed neutrocytosis, and despite appropriate antibacterial coverage, no clinical improvement was noted and the ascitic fluid white cell count increased on repeat paracentesis. Two consecutive ascitic fluid cultures grew Candida glabrata, and antifungal therapy with amphotericin was initiated, pending sensitivity of the isolate. Because of worsening renal function, amphotericin was discontinued and itraconazole was started, as sensitivity of the isolate was then available. Antifungal therapy resulted in resolution of ascitic fluid neutrocytosis and culture negativity. However, the patient's renal function continued to deteriorate, necessitating hemodialysis. Despite multiple courses of antibiotics, she died of fulminant sepsis and multiorgan failure.

KW - Candida glabrata

KW - Spontaneous fungal peritonitis

UR - http://www.scopus.com/inward/record.url?scp=0035079024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035079024&partnerID=8YFLogxK

U2 - 10.1097/00004836-200104000-00020

DO - 10.1097/00004836-200104000-00020

M3 - Article

C2 - 11276287

AN - SCOPUS:0035079024

VL - 32

SP - 362

EP - 364

JO - Journal of Clinical Gastroenterology

JF - Journal of Clinical Gastroenterology

SN - 0192-0790

IS - 4

ER -