The clinical problem of distinguishing acute renal graft rejection from cyclosporine nephrotoxicity has thus far defied solution. Since graft rejection can be thought of as a local manifestation of a generalized immune response, a test demonstrating increased activity of the immune system should be of great diagnostic value. We propose that quantitative analysis of standard Tc-99m radiocolloid spleen-liver scintiscans in serial fashion can provide an indirect clinical estimate of immune system activity. This paper describes a technique for estimating the radiocolloid distribution from spleen-liver scintiscans in renal transplant patients at multiple intervals postoperatively. Some clinical and investigative implications are explored.
|Original language||English (US)|
|Number of pages||6|
|Issue number||1 II|
|State||Published - Apr 29 1987|
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