Bone grafts have been used for decades to achieve successful bone fusion in spinal surgeries. Autograft is the most effective bone graft due to the properties of osteogenesis, osteoconduction, and osteoinduction. However, autograft may not always be available in sufficient quantities, and harvesting may cause patient morbidity. Various ceramic and non-ceramic bone graft extenders have been introduced to limit the need for autograft harvest. These bone substitutes have rapidly evolved in recent years with technological and industrial advancements. Spinal surgeons should closely follow new trends in this industry to achieve the best outcomes for their patients.