Spinal Epidural Lipomatosis: A Review of Pathogenesis, Characteristics, Clinical Presentation, and Management

Keonhee Kim, Joseph Mendelis, Woojin Cho

Research output: Contribution to journalReview article

Abstract

Study Design: Narrative review of available literature. Objective: To summarize current trends in pathogenesis and management of spinal epidural lipomatosis (SEL) and suggest areas where more research would be of benefit. Methods: The available literature relevant to SEL was reviewed. PubMed, Medline, OVID, EMBASE, Cochrane, and Google Scholar were used to review the literature. Institutional review board approval is not applicable for this study. Results: This article clearly summarizes current trends in the pathogenesis and management of SEL. Conclusions: Possible etiologies of SEL include exogenous steroid use, endogenous steroid hormonal disease, obesity, surgery induced, and idiopathic disease. Comorbidities such as acquired immunodeficiency syndrome and Scheuermann’s disease have also been implicated in the pathogenesis of SEL. Steroid-induced SEL seems to have a proclivity for the thoracic region of the spine and has a higher incidence of paraplegia when compared with other forms. Several treatment modalities exist for SEL and are dictated by the underlying cause of the disorder. These include weight reduction, cessation of steroid medications, treatment of underlying endocrine abnormalities, and surgical decompression. Conservative treatments generally aim to decrease the thickness of adipose tissue in the epidural space, but the majority of patients tend to undergo surgical decompression to relieve neurologic symptoms. Surgical decompression provides a statistically significant reduction in symptoms, but postoperative mortality is high, influenced primarily by the patient’s preoperative comorbidities. Physicians should consider the underlying cause of SEL in a given patient before pursuing specific treatment modalities, but alarm symptoms, such as the development of acute cauda equina syndrome, should likely be treated with urgent surgical decompression.

Original languageEnglish (US)
Pages (from-to)658-665
Number of pages8
JournalGlobal Spine Journal
Volume9
Issue number6
DOIs
StatePublished - Sep 1 2019

Fingerprint

Lipomatosis
Surgical Decompression
Steroids
Comorbidity
Scheuermann Disease
Polyradiculopathy
Epidural Space
Paraplegia
Research Ethics Committees
Neurologic Manifestations
PubMed
Adipose Tissue
Weight Loss
Acquired Immunodeficiency Syndrome
Spine
Thorax
Therapeutics
Obesity
Physicians
Mortality

Keywords

  • hormone-induced spinal epidural lipomatosis
  • idiopathic spinal epidural lipomatosis
  • obesity
  • pathogenesis
  • spinal epidural lipomatosis
  • steroid-induced spinal epidural lipomatosis

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

Spinal Epidural Lipomatosis : A Review of Pathogenesis, Characteristics, Clinical Presentation, and Management. / Kim, Keonhee; Mendelis, Joseph; Cho, Woojin.

In: Global Spine Journal, Vol. 9, No. 6, 01.09.2019, p. 658-665.

Research output: Contribution to journalReview article

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