Speed Reduction Does Not Restore High Molecular Weight von Willebrand Multimers During HeartMate II Support: An In Vivo Study

Omar Saeed; Sabarivinoth Rangasamy; Morayma Reyes Gil; Daniel J. Goldstein; Henny H. Billett; Ulrich P. Jorde; Snehal R. Patel

doi:10.1097/MAT.0000000000000831

Speed Reduction Does Not Restore High Molecular Weight von Willebrand Multimers During HeartMate II Support: An In Vivo Study

Omar Saeed, Sabarivinoth Rangasamy, Morayma Reyes Gil, Daniel J. Goldstein, Henny H. Billett, Ulrich P. Jorde, Snehal R. Patel

Research output: Contribution to journal › Article

Abstract

Acquired von Willebrand Syndrome (AVWS) in patients undergoing continuous-flow left ventricular assist device support is due to the loss of von Willebrand factor (vWF) high molecular weight multimers (HMWMs) by shear-mediated mechanisms. We investigated whether reducing speed in vivo would mitigate the shear effect. In outpatients (n = 6) with a HeartMate II, pump speed was decreased to 8,000 rpm for 6 hours. At baseline (9,140 ± 189 rpm), patients had an AVWS as evidenced by low vWF activity:antigen ratios (0.58 ± 0.13, normal >0.7) and reduced HMWMs. After 6 hours, there was no significant change in either the vWF activity:antigen ratio or the HMWMs. Decreasing pump speed does not ameliorate AVWS.

Original language	English (US)
Pages (from-to)	e123-e125
Journal	ASAIO journal (American Society for Artificial Internal Organs : 1992)
Volume	64
Issue number	5
DOIs	https://doi.org/10.1097/MAT.0000000000000831
State	Published - Sep 1 2018

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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Saeed, O., Rangasamy, S., Reyes Gil, M., Goldstein, D. J., Billett, H. H., Jorde, U. P., & Patel, S. R. (2018). Speed Reduction Does Not Restore High Molecular Weight von Willebrand Multimers During HeartMate II Support: An In Vivo Study. ASAIO journal (American Society for Artificial Internal Organs : 1992), 64(5), e123-e125. https://doi.org/10.1097/MAT.0000000000000831

Speed Reduction Does Not Restore High Molecular Weight von Willebrand Multimers During HeartMate II Support : An In Vivo Study. / Saeed, Omar; Rangasamy, Sabarivinoth; Reyes Gil, Morayma ; Goldstein, Daniel J.; Billett, Henny H.; Jorde, Ulrich P.; Patel, Snehal R.

In: ASAIO journal (American Society for Artificial Internal Organs : 1992), Vol. 64, No. 5, 01.09.2018, p. e123-e125.

Research output: Contribution to journal › Article

Saeed, O, Rangasamy, S, Reyes Gil, M , Goldstein, DJ , Billett, HH , Jorde, UP & Patel, SR 2018, 'Speed Reduction Does Not Restore High Molecular Weight von Willebrand Multimers During HeartMate II Support: An In Vivo Study', ASAIO journal (American Society for Artificial Internal Organs : 1992), vol. 64, no. 5, pp. e123-e125. https://doi.org/10.1097/MAT.0000000000000831

Saeed, Omar ; Rangasamy, Sabarivinoth ; Reyes Gil, Morayma ; Goldstein, Daniel J. ; Billett, Henny H. ; Jorde, Ulrich P. ; Patel, Snehal R. / Speed Reduction Does Not Restore High Molecular Weight von Willebrand Multimers During HeartMate II Support : An In Vivo Study. In: ASAIO journal (American Society for Artificial Internal Organs : 1992). 2018 ; Vol. 64, No. 5. pp. e123-e125.

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abstract = "Acquired von Willebrand Syndrome (AVWS) in patients undergoing continuous-flow left ventricular assist device support is due to the loss of von Willebrand factor (vWF) high molecular weight multimers (HMWMs) by shear-mediated mechanisms. We investigated whether reducing speed in vivo would mitigate the shear effect. In outpatients (n = 6) with a HeartMate II, pump speed was decreased to 8,000 rpm for 6 hours. At baseline (9,140 ± 189 rpm), patients had an AVWS as evidenced by low vWF activity:antigen ratios (0.58 ± 0.13, normal >0.7) and reduced HMWMs. After 6 hours, there was no significant change in either the vWF activity:antigen ratio or the HMWMs. Decreasing pump speed does not ameliorate AVWS.",

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