Speech-specific tuning of neurons in human superior temporal gyrus

Alexander M. Chan, Andrew R. Dykstra, Vinay Jayaram, Matthew K. Leonard, Katherine E. Travis, Brian Gygi, Janet M. Baker, Emad Eskandar, Leigh R. Hochberg, Eric Halgren, Sydney S. Cash

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

How the brain extracts words from auditory signals is an unanswered question. We recorded approximately 150 single and multiunits from the left anterior superior temporal gyrus of a patient during multiple auditory experiments. Against low background activity, 45% of units robustly fired to particular spoken words with little or no response to pure tones, noise-vocoded speech, or environmental sounds. Many units were tuned to complex but specific sets of phonemes, which were influenced by local context but invariant to speaker, and suppressed during self-produced speech. The firing of several units to specific visual letters was correlated with their response to the corresponding auditory phonemes, providing the first direct neural evidence for phonological recoding during reading. Maximal decoding of individual phonemes and words identities was attained using firing rates from approximately 5 neurons within 200 ms after word onset. Thus, neurons in human superior temporal gyrus use sparse spatially organized population encoding of complex acoustic-phonetic features to help recognize auditory and visual words.

Original languageEnglish (US)
Pages (from-to)2679-2693
Number of pages15
JournalCerebral Cortex
Volume24
Issue number10
DOIs
StatePublished - 2014

Keywords

  • Audition
  • Human single units
  • Microelectrodes
  • Speech perception
  • Superior temporal gyrus

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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    Chan, A. M., Dykstra, A. R., Jayaram, V., Leonard, M. K., Travis, K. E., Gygi, B., Baker, J. M., Eskandar, E., Hochberg, L. R., Halgren, E., & Cash, S. S. (2014). Speech-specific tuning of neurons in human superior temporal gyrus. Cerebral Cortex, 24(10), 2679-2693. https://doi.org/10.1093/cercor/bht127