Spectrum of pitfalls, pseudolesions, and potential misdiagnoses in cirrhosis

Khaled M. Elsayes, Victoria Chernyak, Ali I. Morshid, An Tang, Ania Z. Kielar, Mustafa R. Bashir, Claude B. Sirlin

Research output: Contribution to journalReview article

4 Scopus citations


OBJECTIVE. The purposes of this article are to review a variety of pitfalls in liver imaging that can lead to the inaccurate diagnosis of focal hepatic lesions in cirrhosis, to describe the pathophysiologic processes of these pitfalls, and to provide specific clues for achieving the correct diagnoses. CONCLUSION. Cirrhosis complicates liver imaging. The distortion and replacement of normal liver parenchyma by fibrous and regenerative tissue can change the typical appearance of many benign lesions, causing them to be misinterpreted as malignancy. In addition, the high incidence and prevalence of hepatocellular carcinoma among patients with cirrhosis put radiologists on high alert for any suspicious findings, especially because not all hepatocellular carcinomas have a typical imaging appearance.

Original languageEnglish (US)
Pages (from-to)87-96
Number of pages10
JournalAmerican Journal of Roentgenology
Issue number1
StatePublished - Jul 1 2018


  • Cirrhosis
  • CT
  • Hepatic focal lesions
  • Hepatocellular carcinoma
  • Mimics
  • MRI
  • Pitfalls

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Elsayes, K. M., Chernyak, V., Morshid, A. I., Tang, A., Kielar, A. Z., Bashir, M. R., & Sirlin, C. B. (2018). Spectrum of pitfalls, pseudolesions, and potential misdiagnoses in cirrhosis. American Journal of Roentgenology, 211(1), 87-96. https://doi.org/10.2214/AJR.18.19781