Spectroscopic imaging of glutamate C4 turnover in human brain

J. W. Pan, D. T. Stein, F. Telang, J. H. Lee, J. Shen, P. Brown, G. Cline, G. F. Mason, G. I. Shulman, D. L. Rothman, H. P. Hetherington

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

One-dimensional spectroscopic imaging of 13C-4-glutamate turnover is performed in the human brain with a 6 cc nominal voxel resolution at 4T. Data were acquired with an indirect detection approach using a short spin echo single quantum 1H-13C heteronuclear editing method and a 7 cm surface coil with quadrature 13C decoupling coils. To analyze the data as a function of tissue type, T1-based image segmentation through the surface coil was performed to determine the gray and white matter contributions to each voxel. The tricarboxylic acid (TCA) cycle rate in gray and white matter was then determined using a two-compartment model with the tissue fractionation derived from the image segmentation. The mean values for the TCA cycle rate for occipital gray and white matter from three volunteers was 0.88 ± 0.12 and 0.28 ± 0.13 respectively, in agreement with literature data. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)673-679
Number of pages7
JournalMagnetic Resonance in Medicine
Volume44
Issue number5
DOIs
Publication statusPublished - Nov 18 2000

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Keywords

  • Glutamate turnover
  • Gray matter
  • H-C
  • Human brain metabolism
  • MR spectroscopic imaging
  • Segmentation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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