Spectroscopic determination of chelator content in antibody - Chelator conjugates: UV-Vis, fluorescence, and MALDI-TOF MS studies

E. Dadachova

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Increasing use of monoclonal antibody-bifunctional chelator conjugates has created a need for quality control procedures providing relatively simple and reliable determination of the chelator-to-protein (C/P) ratio. Spectroscopic methods offer a valuable alternative to the use of radioactive isotapes for that purpose.

Original languageEnglish (US)
Pages (from-to)40-44
Number of pages5
JournalBioPharm
Volume13
Issue number11
StatePublished - 2000

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Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Chelating Agents
Fluorescence
Antibodies
Quality Control
Monoclonal Antibodies
Proteins

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Spectroscopic determination of chelator content in antibody - Chelator conjugates : UV-Vis, fluorescence, and MALDI-TOF MS studies. / Dadachova, E.

In: BioPharm, Vol. 13, No. 11, 2000, p. 40-44.

Research output: Contribution to journalArticle

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