The increasing use of monoclonal antibody-bifunctional chelator conjugates in clinical practice has created the need for quality control procedures providing relatively simple and reliable determination of the chelator-to-protein (C/P) ratio. Spectroscopic methods offer a valuable alternative to the use of radioactive isotopes for this purpose. This article discusses the application of UW/Vis spectrophotometry, fluorescence spectroscopy, and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) for the quality control of MAb-chelator conjugates.
|Original language||English (US)|
|Number of pages||3|
|Journal||Spectroscopy (Santa Monica)|
|State||Published - Dec 1 2000|
ASJC Scopus subject areas
- Analytical Chemistry
- Atomic and Molecular Physics, and Optics