Abstract
The increasing use of monoclonal antibody-bifunctional chelator conjugates in clinical practice has created the need for quality control procedures providing relatively simple and reliable determination of the chelator-to-protein (C/P) ratio. Spectroscopic methods offer a valuable alternative to the use of radioactive isotopes for this purpose. This article discusses the application of UW/Vis spectrophotometry, fluorescence spectroscopy, and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) for the quality control of MAb-chelator conjugates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 30-32 |
| Number of pages | 3 |
| Journal | Spectroscopy (Santa Monica) |
| Volume | 15 |
| Issue number | 1 |
| State | Published - 2000 |
| Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Atomic and Molecular Physics, and Optics
- Spectroscopy