Specificity of synexin-induced chromaffin granule aggregation

Michael Dabrow, Samuel Zaremba, Ruth A. Hogue-Angeletti

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Preparations of synexin (1) exhibit a self-interaction in the absence of chromaffin granules as evidenced by an increase in absorbance at the wave-length used for observing granule aggregation (2). We incorporated this observation into a new formula for calculating the synexin-induced chromaffin granule aggregation. According to this amended analysis, synexin-induced aggregation is specific for chromaffin granules or their membranes. Treatment of intact chromaffin granuleswith trypsin or pronase renders the granules unresponsive to synexin.

Original languageEnglish (US)
Pages (from-to)1164-1171
Number of pages8
JournalTopics in Catalysis
Volume96
Issue number3
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Biophysics
  • Molecular Biology

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