Specification of sense-organ identity by a Caenorhabditis elegans Pax-6 homologue

Yinhua Zhang, Scott W. Emmons

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

The Pax-6 transcription-factor gene, containing a paired domain and a paired-type homeodomain, is conserved in structure and ubiquitously present among Metazoa. It is required for development of the central nervous system, and is mutated in human aniridia, mouse and rat small eye and Drosophila eyeless. We identified the Pax-6 gene of the nematode Caenorhabditis elegans in genetic studies of male tail morphology. C. elegans Pax-6 encodes at least two independent genetic functions. One, like other Pax-6 genes, contains paired and homeodomains; this constitutes the genetic locus vab-3 (ref. 9). The other, described here, is expressed from an internal promoter and contains only the homeodomain portion; this constitutes the genetic locus mab-18 (ref. 7). The mab-18 form of the gene is expressed in a peripheral sense organ and is necessary for specification of sense-organ identity. Its function in this context could be to regulate the expression of cell recognition and adhesion proteins required for sense-organ assembly.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalNature
Volume377
Issue number6544
DOIs
StatePublished - Sep 7 1995

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Sense Organs
Caenorhabditis elegans
Genetic Loci
Genes
Paired Box Transcription Factors
Aniridia
Cell Adhesion
Drosophila
Tail
Central Nervous System
Proteins

ASJC Scopus subject areas

  • General

Cite this

Specification of sense-organ identity by a Caenorhabditis elegans Pax-6 homologue. / Zhang, Yinhua; Emmons, Scott W.

In: Nature, Vol. 377, No. 6544, 07.09.1995, p. 55-59.

Research output: Contribution to journalArticle

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