Specific triiodothyronine binding sites in the anterior pituitary of the rat

Alan R. Schadlow, Martin I. Surks, Harold L. Schwartz, Jack H. Oppenheimer

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Studies with L-[125I]triiodothyronine and L-[ 125I]thyroxine, and with equilibrium dialysis of plasma proteins indicate that rat pituitary binds L-triiodothyronine 9.8 times as strongly as it does L-thyroxine. Injection of even small doses of nonradioactive L-triiodothyronine reduces the pituitary/plasma ratio of radioactive L-triiodothyronine, an indication of the existence of pituitary binding sites with a limited capacity for L-triiodothyronine. Limited capacity binding sites for L-thyroxine could not be demonstrated.

Original languageEnglish (US)
Pages (from-to)1252-1254
Number of pages3
JournalScience
Volume176
Issue number4040
DOIs
StatePublished - Jan 1 1972

ASJC Scopus subject areas

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