Specific triiodothyronine binding sites in the anterior pituitary of the rat

Alan R. Schadlow, Martin I. Surks, Harold L. Schwartz, Jack H. Oppenheimer

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Studies with L-[125I]triiodothyronine and L-[ 125I]thyroxine, and with equilibrium dialysis of plasma proteins indicate that rat pituitary binds L-triiodothyronine 9.8 times as strongly as it does L-thyroxine. Injection of even small doses of nonradioactive L-triiodothyronine reduces the pituitary/plasma ratio of radioactive L-triiodothyronine, an indication of the existence of pituitary binding sites with a limited capacity for L-triiodothyronine. Limited capacity binding sites for L-thyroxine could not be demonstrated.

Original languageEnglish (US)
Pages (from-to)1252-1254
Number of pages3
JournalScience
Volume176
Issue number4040
StatePublished - 1972

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Triiodothyronine
Binding Sites
Thyroxine
Blood Proteins
Dialysis
Injections

ASJC Scopus subject areas

  • General

Cite this

Schadlow, A. R., Surks, M. I., Schwartz, H. L., & Oppenheimer, J. H. (1972). Specific triiodothyronine binding sites in the anterior pituitary of the rat. Science, 176(4040), 1252-1254.

Specific triiodothyronine binding sites in the anterior pituitary of the rat. / Schadlow, Alan R.; Surks, Martin I.; Schwartz, Harold L.; Oppenheimer, Jack H.

In: Science, Vol. 176, No. 4040, 1972, p. 1252-1254.

Research output: Contribution to journalArticle

Schadlow, AR, Surks, MI, Schwartz, HL & Oppenheimer, JH 1972, 'Specific triiodothyronine binding sites in the anterior pituitary of the rat', Science, vol. 176, no. 4040, pp. 1252-1254.
Schadlow AR, Surks MI, Schwartz HL, Oppenheimer JH. Specific triiodothyronine binding sites in the anterior pituitary of the rat. Science. 1972;176(4040):1252-1254.
Schadlow, Alan R. ; Surks, Martin I. ; Schwartz, Harold L. ; Oppenheimer, Jack H. / Specific triiodothyronine binding sites in the anterior pituitary of the rat. In: Science. 1972 ; Vol. 176, No. 4040. pp. 1252-1254.
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