Studies with L-[125I]triiodothyronine and L-[ 125I]thyroxine, and with equilibrium dialysis of plasma proteins indicate that rat pituitary binds L-triiodothyronine 9.8 times as strongly as it does L-thyroxine. Injection of even small doses of nonradioactive L-triiodothyronine reduces the pituitary/plasma ratio of radioactive L-triiodothyronine, an indication of the existence of pituitary binding sites with a limited capacity for L-triiodothyronine. Limited capacity binding sites for L-thyroxine could not be demonstrated.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jan 1 1972|
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