Specific-nuclear triiodothyronine binding sites in rat liver and kidney

J. H. Oppenheimer, D. Koerner, H. L. Schwartz, M. I. Surks

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219 Scopus citations

Abstract

Injection of increasing quantities of L-triiodothyronine (T3) resulted in a progressive decrease in the proportion of T3 bound to the nuclear fraction of rat liver and kidney cells. A similar dose-response relationship could not be demonstrated for other ultracentrifugal fractions. Only a modest reduction in nuclear binding of thyroxine was observed after injection of large amounts of this iodothyronine. The results indicate the presence of relatively specific binding sites for T3 in the nuclei of rat liver and kidney.

Original languageEnglish (US)
Pages (from-to)330-333
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume35
Issue number2
DOIs
Publication statusPublished - Jan 1 1972

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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