Abstract
Insulin-like growth factor II (IGF-II) acts as autocrine growth and motility factor in human rhabdomyosarcoma cell lines, and Northern blot analysis of tumor biopsy specimens from both alveolar and embryonal rhabdomyosarcoma demonstrates high levels of IGF-II mRNA expression. To determine the frequency and site of expression of IGF-II in these tumors, the authors performed in situ hybridization. All tumor specimens examined expressed the gene for IGF-II, and this expression was localized to the tumor cells themselves and not to the surrounding stroma. These data suggest that the IGF-II autocrine loop may be operating not only in vitro but also in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 198-203 |
| Number of pages | 6 |
| Journal | American Journal of Clinical Pathology |
| Volume | 101 |
| Issue number | 2 |
| State | Published - 1994 |
| Externally published | Yes |
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Keywords
- In situ
- Insulin-like growth factors
- Rhabdomyosarcoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Specific expression of insulin-like growth factor-II in rhabdomyosarcoma tumor cells. / Minniti, Caterina P.; Tsokos, M.; Newton, W. A.; Helman, L. J.
In: American Journal of Clinical Pathology, Vol. 101, No. 2, 1994, p. 198-203.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Specific expression of insulin-like growth factor-II in rhabdomyosarcoma tumor cells
AU - Minniti, Caterina P.
AU - Tsokos, M.
AU - Newton, W. A.
AU - Helman, L. J.
PY - 1994
Y1 - 1994
N2 - Insulin-like growth factor II (IGF-II) acts as autocrine growth and motility factor in human rhabdomyosarcoma cell lines, and Northern blot analysis of tumor biopsy specimens from both alveolar and embryonal rhabdomyosarcoma demonstrates high levels of IGF-II mRNA expression. To determine the frequency and site of expression of IGF-II in these tumors, the authors performed in situ hybridization. All tumor specimens examined expressed the gene for IGF-II, and this expression was localized to the tumor cells themselves and not to the surrounding stroma. These data suggest that the IGF-II autocrine loop may be operating not only in vitro but also in vivo.
AB - Insulin-like growth factor II (IGF-II) acts as autocrine growth and motility factor in human rhabdomyosarcoma cell lines, and Northern blot analysis of tumor biopsy specimens from both alveolar and embryonal rhabdomyosarcoma demonstrates high levels of IGF-II mRNA expression. To determine the frequency and site of expression of IGF-II in these tumors, the authors performed in situ hybridization. All tumor specimens examined expressed the gene for IGF-II, and this expression was localized to the tumor cells themselves and not to the surrounding stroma. These data suggest that the IGF-II autocrine loop may be operating not only in vitro but also in vivo.
KW - In situ
KW - Insulin-like growth factors
KW - Rhabdomyosarcoma
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UR - http://www.scopus.com/inward/citedby.url?scp=0028115727&partnerID=8YFLogxK
M3 - Article
C2 - 8116575
AN - SCOPUS:0028115727
VL - 101
SP - 198
EP - 203
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 2
ER -