Special issues in the management of young children, older adults, and the developmentally disabled

R. Eugene Ramsay, W. Donald Shields, Shlomo Shinnar

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The very young, the very old, and those with developmental disability have an increased risk of both epilepsy and prolonged and repetitive seizures. The special issues that affect their management are reviewed. Polypharmacy that occurs because of comorbid illnesses requiring chronic medication can result in dangerous drug-drug interactions. The antiepileptic drug's pharmacokinetic profile must be factored when treating young children and older adults. Patients who have taken an older enzyme-inducing antiepileptic drug for years may have a markedly induced hepatic enzyme system that may alter drug metabolism. Overdose or toxicity may occur in older adults who may metabolize and clear antiepileptic drugs more slowly than younger patients. Benzodiazepines are the most rapidly effective acute therapy for repetitive or prolonged seizures. It is important to have a plan for management of prolonged and repetitive seizures. Long-term therapy should be managed in a manner that will eliminate the need for rescue therapies and visits to the emergency department.

Original languageEnglish (US)
JournalJournal of Child Neurology
Volume22
Issue number5 SUPPL.
DOIs
StatePublished - May 2007

Fingerprint

Anticonvulsants
Seizures
Polypharmacy
Developmental Disabilities
Enzymes
Benzodiazepines
Drug Interactions
Pharmaceutical Preparations
Hospital Emergency Service
Epilepsy
Chronic Disease
Therapeutics
Pharmacokinetics
Liver

Keywords

  • Antiepileptic drugs
  • Epilepsy
  • Mental disability

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Special issues in the management of young children, older adults, and the developmentally disabled. / Ramsay, R. Eugene; Shields, W. Donald; Shinnar, Shlomo.

In: Journal of Child Neurology, Vol. 22, No. 5 SUPPL., 05.2007.

Research output: Contribution to journalArticle

@article{14602a9b748445a7a7412c99013b0bb5,
title = "Special issues in the management of young children, older adults, and the developmentally disabled",
abstract = "The very young, the very old, and those with developmental disability have an increased risk of both epilepsy and prolonged and repetitive seizures. The special issues that affect their management are reviewed. Polypharmacy that occurs because of comorbid illnesses requiring chronic medication can result in dangerous drug-drug interactions. The antiepileptic drug's pharmacokinetic profile must be factored when treating young children and older adults. Patients who have taken an older enzyme-inducing antiepileptic drug for years may have a markedly induced hepatic enzyme system that may alter drug metabolism. Overdose or toxicity may occur in older adults who may metabolize and clear antiepileptic drugs more slowly than younger patients. Benzodiazepines are the most rapidly effective acute therapy for repetitive or prolonged seizures. It is important to have a plan for management of prolonged and repetitive seizures. Long-term therapy should be managed in a manner that will eliminate the need for rescue therapies and visits to the emergency department.",
keywords = "Antiepileptic drugs, Epilepsy, Mental disability",
author = "Ramsay, {R. Eugene} and Shields, {W. Donald} and Shlomo Shinnar",
year = "2007",
month = "5",
doi = "10.1177/0883073807303253",
language = "English (US)",
volume = "22",
journal = "Journal of Child Neurology",
issn = "0883-0738",
publisher = "SAGE Publications Inc.",
number = "5 SUPPL.",

}

TY - JOUR

T1 - Special issues in the management of young children, older adults, and the developmentally disabled

AU - Ramsay, R. Eugene

AU - Shields, W. Donald

AU - Shinnar, Shlomo

PY - 2007/5

Y1 - 2007/5

N2 - The very young, the very old, and those with developmental disability have an increased risk of both epilepsy and prolonged and repetitive seizures. The special issues that affect their management are reviewed. Polypharmacy that occurs because of comorbid illnesses requiring chronic medication can result in dangerous drug-drug interactions. The antiepileptic drug's pharmacokinetic profile must be factored when treating young children and older adults. Patients who have taken an older enzyme-inducing antiepileptic drug for years may have a markedly induced hepatic enzyme system that may alter drug metabolism. Overdose or toxicity may occur in older adults who may metabolize and clear antiepileptic drugs more slowly than younger patients. Benzodiazepines are the most rapidly effective acute therapy for repetitive or prolonged seizures. It is important to have a plan for management of prolonged and repetitive seizures. Long-term therapy should be managed in a manner that will eliminate the need for rescue therapies and visits to the emergency department.

AB - The very young, the very old, and those with developmental disability have an increased risk of both epilepsy and prolonged and repetitive seizures. The special issues that affect their management are reviewed. Polypharmacy that occurs because of comorbid illnesses requiring chronic medication can result in dangerous drug-drug interactions. The antiepileptic drug's pharmacokinetic profile must be factored when treating young children and older adults. Patients who have taken an older enzyme-inducing antiepileptic drug for years may have a markedly induced hepatic enzyme system that may alter drug metabolism. Overdose or toxicity may occur in older adults who may metabolize and clear antiepileptic drugs more slowly than younger patients. Benzodiazepines are the most rapidly effective acute therapy for repetitive or prolonged seizures. It is important to have a plan for management of prolonged and repetitive seizures. Long-term therapy should be managed in a manner that will eliminate the need for rescue therapies and visits to the emergency department.

KW - Antiepileptic drugs

KW - Epilepsy

KW - Mental disability

UR - http://www.scopus.com/inward/record.url?scp=34250679356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250679356&partnerID=8YFLogxK

U2 - 10.1177/0883073807303253

DO - 10.1177/0883073807303253

M3 - Article

C2 - 17690088

AN - SCOPUS:34250679356

VL - 22

JO - Journal of Child Neurology

JF - Journal of Child Neurology

SN - 0883-0738

IS - 5 SUPPL.

ER -