Abstract
Neurons exhibit spatial compartmentalization of gene expression where localization of messenger RNAs (mRNAs) to distal processes allows for site-specific distribution of proteins through local translation. Recently, there have been reports of coordination between mRNA transport with vesicular and organellar trafficking. In this review, we will highlight the latest literature on axonal and dendritic local protein synthesis with links to mRNA–organelle cotransport followed by emerging technologies necessary to study these phenomena. Recent high-resolution imaging studies have led to insights into the dynamics of RNA–organelle interactions, and we can now peer into these intricate interactions within subcellular compartments of neurons.
Original language | English (US) |
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Article number | 663367 |
Journal | Frontiers in Cell and Developmental Biology |
Volume | 9 |
DOIs | |
State | Published - Jun 10 2021 |
Keywords
- high-resolution imaging
- mRNA translation
- mRNA transport
- neurons
- organellar trafficking
- single molecule imaging
- vesicular trafficking
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology