Spatial regulation of tumor cell protrusions by RhoC

Jose Javier Bravo-Cordero, Louis Hodgson, John S. Condeelis

Research output: Contribution to journalComment/debate

21 Scopus citations

Abstract

Systemic metastasis is the dissemination of cancer cells from the primary tumor to distant organs and is the primary cause of death in cancer patients. How do cancer cells leave the primary tumor mass? The ability of the tumor cells to form different types of actin-rich protrusions including invasive protrusions (invadopodia) and locomotory protrusions (lamellipodia [2D] or pseudopodia [3D]), facilitate the invasion and dissemination of the tumor cells. Rho-family of p21 small GTPases plays a direct role in regulating the actin dynamics in these intracellular compartments. Recent studies have shown that the signaling molecules including RhoC/p190RhoGEF/p190RhoGAP acts as a "molecular compass" in order to direct the spatial and temporal dynamics of the formation of these invasive and locomotory protrusions leading to efficient invasion.

Original languageEnglish (US)
Pages (from-to)263-267
Number of pages5
JournalCell Adhesion and Migration
Volume8
Issue number3
DOIs
StatePublished - May 1 2014

Keywords

  • Actin cytoskeleton
  • Chemotaxis
  • Cofilin
  • Invadopodia
  • Lamellipodia
  • P190RhoGAP
  • P190RhoGEF
  • RhoA
  • RhoC

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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