TY - JOUR
T1 - Spatial navigation and risk of cognitive impairment
T2 - A prospective cohort study
AU - Verghese, Joe
AU - Lipton, Richard
AU - Ayers, Emmeline
N1 - Funding Information:
The Einstein Aging Study was supported by the National Institute on Aging (grant PO1 AGO3949). J.A. and E.A. were supported by the National Institute on Aging (RO1 AGO44007 and R01 AG036921). R.L. has received research support from the National Institutes of Health (PO1 AG03949 [program director, project and core leader], RO1AG025119, RO1AG022374-06A2, RO1AG034119, and RO1AG12101) and the National Headache Foundation.
Publisher Copyright:
© 2017 the Alzheimer's Association
PY - 2017/9
Y1 - 2017/9
N2 - Introduction Spatial navigation deficits are reported in dementia, but their temporal relationship to cognitive decline is not established. Methods This is a prospective cohort study in 442 nondemented adults (mean age 79.9 years). Spatial navigation measured with the Floor Maze Test and reported as immediate maze time (IMT) and delayed maze time (DMT). Predementia syndromes, mild cognitive impairment syndrome (MCI) and motoric cognitive risk syndrome (MCR), were primary outcomes. Results Over a mean follow-up of 16.5 ± 13.7 months, 41 participants developed MCI and 30 participants developed MCR. In Cox models adjusted for age, sex, education, cognitive status, comorbid illnesses, and maze errors, a 10-second increment on IMT predicted incident MCI (adjusted hazard ratio [aHR]: 1.25; 95% confidence interval [CI]: 1.06–1.48) and MCR (aHR: 1.53; 95% CI: 1.23–1.90). DMT predicted MCR but not MCI. Discussion Spatial navigation performance predicted predementia syndromes in aging and implicates navigational impairments as an early feature in dementias.
AB - Introduction Spatial navigation deficits are reported in dementia, but their temporal relationship to cognitive decline is not established. Methods This is a prospective cohort study in 442 nondemented adults (mean age 79.9 years). Spatial navigation measured with the Floor Maze Test and reported as immediate maze time (IMT) and delayed maze time (DMT). Predementia syndromes, mild cognitive impairment syndrome (MCI) and motoric cognitive risk syndrome (MCR), were primary outcomes. Results Over a mean follow-up of 16.5 ± 13.7 months, 41 participants developed MCI and 30 participants developed MCR. In Cox models adjusted for age, sex, education, cognitive status, comorbid illnesses, and maze errors, a 10-second increment on IMT predicted incident MCI (adjusted hazard ratio [aHR]: 1.25; 95% confidence interval [CI]: 1.06–1.48) and MCR (aHR: 1.53; 95% CI: 1.23–1.90). DMT predicted MCR but not MCI. Discussion Spatial navigation performance predicted predementia syndromes in aging and implicates navigational impairments as an early feature in dementias.
KW - Cognitive tests
KW - Dementia
KW - Incidence studies
KW - Mild cognitive impairment syndrome
KW - Motoric cognitive risk syndrome
KW - Navigation
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U2 - 10.1016/j.jalz.2017.01.023
DO - 10.1016/j.jalz.2017.01.023
M3 - Article
C2 - 28264767
AN - SCOPUS:85015645552
SN - 1552-5260
VL - 13
SP - 985
EP - 992
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 9
ER -
