Spatial distribution of long-term potentiation in the surround of visual cortex lesions in vitro

Carolin I. Dohle, Ulf T. Eysel, Thomas Mittmann

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Focal visual cortex lesions lead to functional changes in the surrounding cortical network, possibly mediated through synaptic long-term potentiation (LTP). Although a post-lesional facilitation of LTP has been observed, nothing is known about the spatial profile of LTP in the normal and focally lesioned visual cortex of rats. We used a 64-multielectrode array to characterise the spread of LTP induced by theta-burst stimulation in layer IV. Measurements were made at comparable distances from the midline in the visual cortex of controls, sham-operated and lesioned animals. In control rats, LTP was elicited in projections to all visual cortex layers. However, we completely failed to observe LTP in sham-operated animals 1-4 days after surgery. At comparable survival times, no LTP could be elicited in the lesion-treated rats in direct vicinity of the border of the injury, while LTP was successfully induced at larger distances from the lesion. The maximal reach of this restored post-lesion LTP was spatially more limited than in controls and equal in all directions, accordingly absolute distance and not maximal length or density of connections seems to rule local lesion-induced functional remodelling.

Original languageEnglish (US)
Pages (from-to)423-433
Number of pages11
JournalExperimental Brain Research
Volume199
Issue number3-4
DOIs
StatePublished - Dec 2009

Keywords

  • Connectivity
  • LTP
  • Lesion
  • Plasticity
  • Reorganisation
  • Visual cortex

ASJC Scopus subject areas

  • Neuroscience(all)

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