Spatial and temporal distributions of lung cancer histopathology in the state of Maine

Howard D. Hosgood, Christopher Farah, Candice C. Black, Molly Schwenn, Janet M. Hock

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Maine has among the highest rates of lung cancer in the United States (US). Maine serves as a geographical representation of US rural communities, and their associated health disparities. As the key risks of tobacco use decrease and radon abatement increases, previously obscured environmental exposures may measurably contribute to the attributable risk fraction of lung cancer. To generate hypotheses of novel environmental exposures associated with lung cancer, we investigated if there was non-random spatial distribution of lung cancer in Maine. Case data (n= 14,038) between 1995 and 2006 were obtained from the Maine Cancer Registry. Population data were obtained from the 2000 US Census. We assessed the spatial distribution of lung cancers among white cases by histopathology subtype [non-small cell lung carcinoma (NSCLC): adenocarcinoma (n= 3680), squamous cell (n= 2801) and large cell (n= 1195); and small cell lung carcinoma (SCLC) (n= 1994)], using spatial scan statistic, assuming a discrete Poisson distribution adjusted for age and population density. Because of time-dependent trends in lung cancer differential diagnostic criteria, we repeated our analyses, limiting it to 2002-2006. While SCLC rates were equivalent across the state, we identified discrete regions with elevated rates of adenocarcinoma among females and squamous cell carcinoma among males. Independent of gender, the most striking geospatial observation was elevated large cell lung cancer specifically in one of the poorest counties in the US. A selective spatial distribution of large cell lung cancer has not been previously reported. More research is needed to identify factors inducing large cell carcinoma pathology, and to determine if in rural communities health disparities are associated with increased risk for this diagnosis.

Original languageEnglish (US)
Pages (from-to)55-62
Number of pages8
JournalLung Cancer
Volume82
Issue number1
DOIs
StatePublished - Oct 2013

Fingerprint

Lung Neoplasms
Small Cell Lung Carcinoma
Environmental Exposure
Rural Population
Poisson Distribution
Large Cell Carcinoma
Rural Health
Radon
Tobacco Use
Censuses
Population Density
Non-Small Cell Lung Carcinoma
Registries
Squamous Cell Carcinoma
Adenocarcinoma
Epithelial Cells
Observation
Pathology
Health
Research

Keywords

  • Lung cancer
  • New England
  • Radon
  • Subtype
  • Wood

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Spatial and temporal distributions of lung cancer histopathology in the state of Maine. / Hosgood, Howard D.; Farah, Christopher; Black, Candice C.; Schwenn, Molly; Hock, Janet M.

In: Lung Cancer, Vol. 82, No. 1, 10.2013, p. 55-62.

Research output: Contribution to journalArticle

Hosgood, Howard D. ; Farah, Christopher ; Black, Candice C. ; Schwenn, Molly ; Hock, Janet M. / Spatial and temporal distributions of lung cancer histopathology in the state of Maine. In: Lung Cancer. 2013 ; Vol. 82, No. 1. pp. 55-62.
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