SOS induction by stabilized topoisomerase IA cleavage complex occurs via the RecBCD pathway

Jeanette H. Sutherland, Bokun Cheng, I. Fen Liu, Yuk Ching Tse-Dinh

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Accumulation of mutant topoisomerase I cleavage complex can lead to SOS induction and cell death in Escherichia coli. The single-stranded break associated with mutant topoisomerase I cleavage complex is converted to double-stranded break, which then is processed by the RecBCD pathway, followed by association of RecA with the single-stranded DNA.

Original languageEnglish (US)
Pages (from-to)3399-3403
Number of pages5
JournalJournal of Bacteriology
Volume190
Issue number9
DOIs
StatePublished - May 2008

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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