Some effects of intracerebral lead implantation in the rat

Asao Hirano, Joseph A. Kochen

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Pellets of lead acetate were implanted into the forebrains of adult rats which were sacrificed at intervals between 4 days and 4 weeks thereafter. Parenchymal necrosis and a number of reactive changes including edema and macrophage invasion were observed. Lead deposits were found in the extracellular spaces and within macrophages but only to a slight extent within glial or meningeal cells. Vascular changes were quite remarkable and included proliferation and the appearance of fenestrated blood vessels as well as some with tubular bodies and striking increases in the number of pinocytotic vesicles.

Original languageEnglish (US)
Pages (from-to)307-315
Number of pages9
JournalActa neuropathologica
Issue number4
StatePublished - Dec 1 1975


  • Brain edema
  • Endothelial fenestrations
  • Lead
  • Pinocytotic vesicles

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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