Abstract
Pellets of lead acetate were implanted into the forebrains of adult rats which were sacrificed at intervals between 4 days and 4 weeks thereafter. Parenchymal necrosis and a number of reactive changes including edema and macrophage invasion were observed. Lead deposits were found in the extracellular spaces and within macrophages but only to a slight extent within glial or meningeal cells. Vascular changes were quite remarkable and included proliferation and the appearance of fenestrated blood vessels as well as some with tubular bodies and striking increases in the number of pinocytotic vesicles.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 307-315 |
| Number of pages | 9 |
| Journal | Acta Neuropathologica |
| Volume | 33 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1975 |
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Keywords
- Brain edema
- Endothelial fenestrations
- Lead
- Pinocytotic vesicles
ASJC Scopus subject areas
- Neuroscience(all)
- Pathology and Forensic Medicine
- Clinical Neurology
Cite this
Some effects of intracerebral lead implantation in the rat. / Hirano, Asao; Kochen, Joseph A.
In: Acta Neuropathologica, Vol. 33, No. 4, 12.1975, p. 307-315.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Some effects of intracerebral lead implantation in the rat
AU - Hirano, Asao
AU - Kochen, Joseph A.
PY - 1975/12
Y1 - 1975/12
N2 - Pellets of lead acetate were implanted into the forebrains of adult rats which were sacrificed at intervals between 4 days and 4 weeks thereafter. Parenchymal necrosis and a number of reactive changes including edema and macrophage invasion were observed. Lead deposits were found in the extracellular spaces and within macrophages but only to a slight extent within glial or meningeal cells. Vascular changes were quite remarkable and included proliferation and the appearance of fenestrated blood vessels as well as some with tubular bodies and striking increases in the number of pinocytotic vesicles.
AB - Pellets of lead acetate were implanted into the forebrains of adult rats which were sacrificed at intervals between 4 days and 4 weeks thereafter. Parenchymal necrosis and a number of reactive changes including edema and macrophage invasion were observed. Lead deposits were found in the extracellular spaces and within macrophages but only to a slight extent within glial or meningeal cells. Vascular changes were quite remarkable and included proliferation and the appearance of fenestrated blood vessels as well as some with tubular bodies and striking increases in the number of pinocytotic vesicles.
KW - Brain edema
KW - Endothelial fenestrations
KW - Lead
KW - Pinocytotic vesicles
UR - http://www.scopus.com/inward/record.url?scp=0016765534&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016765534&partnerID=8YFLogxK
U2 - 10.1007/BF00686162
DO - 10.1007/BF00686162
M3 - Article
C2 - 175628
AN - SCOPUS:0016765534
VL - 33
SP - 307
EP - 315
JO - Acta Neuropathologica
JF - Acta Neuropathologica
SN - 0001-6322
IS - 4
ER -