Somatic symptoms in treatment-resistant depression

George I. Papakostas; Timothy Petersen; John Denninger; Shamsah B. Sonawalla; Yasmin Mahal; Jonathan E. Alpert; Andrew A. Nierenberg; Maurizio Fava

doi:10.1016/S0165-1781(03)00063-5

Somatic symptoms in treatment-resistant depression

George I. Papakostas, Timothy Petersen, John Denninger, Shamsah B. Sonawalla, Yasmin Mahal, Jonathan E. Alpert, Andrew A. Nierenberg, Maurizio Fava

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

The purpose of this work was to study the prevalence of somatic symptoms in patients with treatment-resistant depression (TRD) and their impact on the response to antidepressant treatment. Somatic symptoms were assessed during the screen visit with the Symptom Questionnaire (SQ) somatic symptom (SQ-SS) and somatic well-being sub-scales (SQ-SWB) in 40 patients with TRD enrolled in a 6-week open trial of nortriptyline. A logistic regression was used to test whether SQ-SS or SQ-SWB scores predicted clinical response to nortriptyline. Ninety-five percent of patients reported at least one somatic symptom. Higher SQ-SS scores during the screen visit predicted poorer response to nortriptyline. There was a trend for lower SQ-SWB scores to predict poor response to nortriptyline. None of the patients with SQ-SS scores above the mean for the sample responded to nortriptyline. The overwhelming majority of patients with TRD presented with somatic symptoms. In addition, a greater number of somatic symptoms during the screen visit placed patients at risk for further treatment resistance.

Original language	English (US)
Pages (from-to)	39-45
Number of pages	7
Journal	Psychiatry Research
Volume	118
Issue number	1
DOIs	https://doi.org/10.1016/S0165-1781(03)00063-5
State	Published - May 1 2003
Externally published	Yes

Keywords

Antidepressants
Nortriptyline
Response prediction
Symptom Questionnaire

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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abstract = "The purpose of this work was to study the prevalence of somatic symptoms in patients with treatment-resistant depression (TRD) and their impact on the response to antidepressant treatment. Somatic symptoms were assessed during the screen visit with the Symptom Questionnaire (SQ) somatic symptom (SQ-SS) and somatic well-being sub-scales (SQ-SWB) in 40 patients with TRD enrolled in a 6-week open trial of nortriptyline. A logistic regression was used to test whether SQ-SS or SQ-SWB scores predicted clinical response to nortriptyline. Ninety-five percent of patients reported at least one somatic symptom. Higher SQ-SS scores during the screen visit predicted poorer response to nortriptyline. There was a trend for lower SQ-SWB scores to predict poor response to nortriptyline. None of the patients with SQ-SS scores above the mean for the sample responded to nortriptyline. The overwhelming majority of patients with TRD presented with somatic symptoms. In addition, a greater number of somatic symptoms during the screen visit placed patients at risk for further treatment resistance.",

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AU - Sonawalla, Shamsah B.

AU - Mahal, Yasmin

AU - Alpert, Jonathan E.

AU - Nierenberg, Andrew A.

AU - Fava, Maurizio

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Somatic symptoms in treatment-resistant depression

Abstract

Keywords

ASJC Scopus subject areas

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