Abstract
The purpose of this work was to study the prevalence of somatic symptoms in patients with treatment-resistant depression (TRD) and their impact on the response to antidepressant treatment. Somatic symptoms were assessed during the screen visit with the Symptom Questionnaire (SQ) somatic symptom (SQ-SS) and somatic well-being sub-scales (SQ-SWB) in 40 patients with TRD enrolled in a 6-week open trial of nortriptyline. A logistic regression was used to test whether SQ-SS or SQ-SWB scores predicted clinical response to nortriptyline. Ninety-five percent of patients reported at least one somatic symptom. Higher SQ-SS scores during the screen visit predicted poorer response to nortriptyline. There was a trend for lower SQ-SWB scores to predict poor response to nortriptyline. None of the patients with SQ-SS scores above the mean for the sample responded to nortriptyline. The overwhelming majority of patients with TRD presented with somatic symptoms. In addition, a greater number of somatic symptoms during the screen visit placed patients at risk for further treatment resistance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 39-45 |
| Number of pages | 7 |
| Journal | Psychiatry Research |
| Volume | 118 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 1 2003 |
| Externally published | Yes |
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Keywords
- Antidepressants
- Nortriptyline
- Response prediction
- Symptom Questionnaire
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Somatic symptoms in treatment-resistant depression. / Papakostas, George I.; Petersen, Timothy; Denninger, John; Sonawalla, Shamsah B.; Mahal, Yasmin; Alpert, Jonathan E.; Nierenberg, Andrew A.; Fava, Maurizio.
In: Psychiatry Research, Vol. 118, No. 1, 01.05.2003, p. 39-45.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Somatic symptoms in treatment-resistant depression
AU - Papakostas, George I.
AU - Petersen, Timothy
AU - Denninger, John
AU - Sonawalla, Shamsah B.
AU - Mahal, Yasmin
AU - Alpert, Jonathan E.
AU - Nierenberg, Andrew A.
AU - Fava, Maurizio
PY - 2003/5/1
Y1 - 2003/5/1
N2 - The purpose of this work was to study the prevalence of somatic symptoms in patients with treatment-resistant depression (TRD) and their impact on the response to antidepressant treatment. Somatic symptoms were assessed during the screen visit with the Symptom Questionnaire (SQ) somatic symptom (SQ-SS) and somatic well-being sub-scales (SQ-SWB) in 40 patients with TRD enrolled in a 6-week open trial of nortriptyline. A logistic regression was used to test whether SQ-SS or SQ-SWB scores predicted clinical response to nortriptyline. Ninety-five percent of patients reported at least one somatic symptom. Higher SQ-SS scores during the screen visit predicted poorer response to nortriptyline. There was a trend for lower SQ-SWB scores to predict poor response to nortriptyline. None of the patients with SQ-SS scores above the mean for the sample responded to nortriptyline. The overwhelming majority of patients with TRD presented with somatic symptoms. In addition, a greater number of somatic symptoms during the screen visit placed patients at risk for further treatment resistance.
AB - The purpose of this work was to study the prevalence of somatic symptoms in patients with treatment-resistant depression (TRD) and their impact on the response to antidepressant treatment. Somatic symptoms were assessed during the screen visit with the Symptom Questionnaire (SQ) somatic symptom (SQ-SS) and somatic well-being sub-scales (SQ-SWB) in 40 patients with TRD enrolled in a 6-week open trial of nortriptyline. A logistic regression was used to test whether SQ-SS or SQ-SWB scores predicted clinical response to nortriptyline. Ninety-five percent of patients reported at least one somatic symptom. Higher SQ-SS scores during the screen visit predicted poorer response to nortriptyline. There was a trend for lower SQ-SWB scores to predict poor response to nortriptyline. None of the patients with SQ-SS scores above the mean for the sample responded to nortriptyline. The overwhelming majority of patients with TRD presented with somatic symptoms. In addition, a greater number of somatic symptoms during the screen visit placed patients at risk for further treatment resistance.
KW - Antidepressants
KW - Nortriptyline
KW - Response prediction
KW - Symptom Questionnaire
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UR - http://www.scopus.com/inward/citedby.url?scp=0037621668&partnerID=8YFLogxK
U2 - 10.1016/S0165-1781(03)00063-5
DO - 10.1016/S0165-1781(03)00063-5
M3 - Article
VL - 118
SP - 39
EP - 45
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 1
ER -