TY - JOUR
T1 - Somatic symptoms as predictors of time to onset of response to fluoxetine in major depressive disorder
AU - Papakostas, George I.
AU - Petersen, Timothy J.
AU - Iosifescu, Dan V.
AU - Summergrad, Paul
AU - Sklarsky, Katherine G.
AU - Alpert, Jonathan E.
AU - Nierenberg, Andrew A.
AU - Fava, Maurizio
PY - 2004/4
Y1 - 2004/4
N2 - Objective: In the present study we assessed the relationship between somatic symptoms and the time to onset of clinical response to fluoxetine in patients with major depressive disorder (MDD). Method: 87 outpatients (mean age = 41.4 ± 10.2 years; 59.8% women) with DSM-III-R MDD who had sustained acute response to fluoxetine completed the Symptom Questionnaire (SQ) at baseline. Onset of response was defined as a 30% decrease in the total score for the 17-item Hamilton Rating Scale for Depression that led to a 50% decrease by week 8. With the use of 2 separate multiple regressions, controlling for the severity of depression at baseline, we then assessed the relationship between the number of somatic symptoms as assessed by the SQ subscale for somatic symptoms (SQ-SS) and both the time to onset of clinical response and the time to clinical response. The study was conducted between November 1992 and January 1999. Results: A greater number of somatic symptoms at baseline predicted a greater amount of time to onset of clinical response to fluoxetine (p = .0233). The relationship between SQ-SS scores and time to response was not found to be statistically significant (p > .05). Conclusion: Somatic symptoms of depression were found to be associated with a delayed onset of antidepressant response to fluoxetine in MDD.
AB - Objective: In the present study we assessed the relationship between somatic symptoms and the time to onset of clinical response to fluoxetine in patients with major depressive disorder (MDD). Method: 87 outpatients (mean age = 41.4 ± 10.2 years; 59.8% women) with DSM-III-R MDD who had sustained acute response to fluoxetine completed the Symptom Questionnaire (SQ) at baseline. Onset of response was defined as a 30% decrease in the total score for the 17-item Hamilton Rating Scale for Depression that led to a 50% decrease by week 8. With the use of 2 separate multiple regressions, controlling for the severity of depression at baseline, we then assessed the relationship between the number of somatic symptoms as assessed by the SQ subscale for somatic symptoms (SQ-SS) and both the time to onset of clinical response and the time to clinical response. The study was conducted between November 1992 and January 1999. Results: A greater number of somatic symptoms at baseline predicted a greater amount of time to onset of clinical response to fluoxetine (p = .0233). The relationship between SQ-SS scores and time to response was not found to be statistically significant (p > .05). Conclusion: Somatic symptoms of depression were found to be associated with a delayed onset of antidepressant response to fluoxetine in MDD.
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U2 - 10.4088/JCP.v65n0414
DO - 10.4088/JCP.v65n0414
M3 - Article
C2 - 15119918
AN - SCOPUS:2442482557
SN - 0160-6689
VL - 65
SP - 543
EP - 546
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
IS - 4
ER -