Somatic polyploidization and cellular proliferation drive body size evolution in nematodes

Anthony J. Flemming, Zai Zhong Shen, Ana Cunha, Scott W. Emmons, Armand M. Leroi

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Most of the hypodermis of a rhabditid nematode such as Caenorhabditis elegans is a single syncytium. The size of this syncytium (as measured by body size) has evolved repeatedly in the rhabditid nematodes. Two cellular mechanisms are important in the evolution of body size: changes in the numbers of cells that fuse with the syncytium, and the extent of its acellular growth. Thus nematodes differ from mammals and other invertebrates in which body size evolution is caused by changes in cell number alone. The evolution of acellular syncytial growth in nematodes is also associated with changes in the ploidy of hypodermal nuclei. These nuclei are polyploid as a consequence of iterative rounds of endoreduplication, and this endocycle has evolved repeatedly. The association between acellular growth and endoreduplication is also seen in C. elegans mutations that interrupt transforming growth factor-β signaling and that result in dwarfism and deficiencies in hypodermal ploidy. The transforming growth factor-β pathway is a candidate for being involved in nematode body size evolution.

Original languageEnglish (US)
Pages (from-to)5285-5290
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number10
DOIs
StatePublished - May 9 2000

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Body Size
Giant Cells
Endoreduplication
Cell Proliferation
Ploidies
Caenorhabditis elegans
Transforming Growth Factors
Growth
Cell Count
Dwarfism
Polyploidy
Subcutaneous Tissue
Invertebrates
Mammals
Mutation

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Somatic polyploidization and cellular proliferation drive body size evolution in nematodes. / Flemming, Anthony J.; Shen, Zai Zhong; Cunha, Ana; Emmons, Scott W.; Leroi, Armand M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 10, 09.05.2000, p. 5285-5290.

Research output: Contribution to journalArticle

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