Somatic hypermutation of antibody genes: A hot spot warms up

Nancy S. Green, Mark M. Lin, Matthew D. Scharff

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

In the course of an immune response, antibodies undergo affinity maturation in order to increase their efficiency in neutralizing foreign invaders. Affinity maturation occurs by the introduction of multiple point mutations in the variable region gene that encodes the antigen binding site. This somatic hypermutation is restricted to immunoglobulin genes and occurs at very high rates. The precise molecular basis of this process remains obscure. However, recent studies using a variety of in vivo and in vitro systems have revealed important regulatory regions, base motifs that are preferred targets of mutation and evidence that transcription may play an active role in hypermutation.

Original languageEnglish (US)
Pages (from-to)227-234
Number of pages8
JournalBioEssays
Volume20
Issue number3
DOIs
StatePublished - Mar 1998

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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