Somatic cell genetics of immunoglobulin production

Research output: Contribution to journalArticle


Tissue culture lines of mouse myeloma cells have been used to study the somatic cell genetics of immunoglobulin production. Assays have been developed to identify and quantify mutants that have undergone changes in either the synthesis or structure of the immunoglobulin molecule. All of the classical types of mutants have been identified. What is unusual is that these mutants arise at a very high frequency. This genetic instability seems to be restricted to immunoglobulin genes. The fusion of mutant and wild-type cells allows the study of interaction of genes and gene products.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalCellular Immunology
Issue number1
Publication statusPublished - Jan 1 1982


ASJC Scopus subject areas

  • Immunology

Cite this