Somatic cell genetics of immunoglobulin production

Research output: Contribution to journalArticle

Abstract

Tissue culture lines of mouse myeloma cells have been used to study the somatic cell genetics of immunoglobulin production. Assays have been developed to identify and quantify mutants that have undergone changes in either the synthesis or structure of the immunoglobulin molecule. All of the classical types of mutants have been identified. What is unusual is that these mutants arise at a very high frequency. This genetic instability seems to be restricted to immunoglobulin genes. The fusion of mutant and wild-type cells allows the study of interaction of genes and gene products.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalCellular Immunology
Volume66
Issue number1
StatePublished - 1982

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Immunoglobulins
Immunoglobulin Genes
Genes

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Somatic cell genetics of immunoglobulin production. / Scharff, Matthew D.

In: Cellular Immunology, Vol. 66, No. 1, 1982, p. 29-33.

Research output: Contribution to journalArticle

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