Solvent-controlled Csp2→O silyl migration: The "one-pot" synthesis of 2,3-disubsituted thiophenes

Nelmi O. Devarie-Baez, Brian J. Shuhler, Hua Wang, Ming Xian

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

(Chemical Equation Presented) An effective "one-pot" synthesis of disubstituted thiophene derivatives employing 3-bromo-2-silyl thiophenes has been developed. A solvent-controlled [1,4] Csp2→O silyl migration was involved as the key step in this process.

Original languageEnglish (US)
Pages (from-to)4655-4658
Number of pages4
JournalOrganic Letters
Volume9
Issue number22
DOIs
StatePublished - Oct 25 2007
Externally publishedYes

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Thiophenes
thiophenes
synthesis
Derivatives

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Solvent-controlled Csp2→O silyl migration : The "one-pot" synthesis of 2,3-disubsituted thiophenes. / Devarie-Baez, Nelmi O.; Shuhler, Brian J.; Wang, Hua; Xian, Ming.

In: Organic Letters, Vol. 9, No. 22, 25.10.2007, p. 4655-4658.

Research output: Contribution to journalArticle

Devarie-Baez, Nelmi O. ; Shuhler, Brian J. ; Wang, Hua ; Xian, Ming. / Solvent-controlled Csp2→O silyl migration : The "one-pot" synthesis of 2,3-disubsituted thiophenes. In: Organic Letters. 2007 ; Vol. 9, No. 22. pp. 4655-4658.
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