Solution NMR of membrane proteins in bilayer mimics: Small is beautiful, but sometimes bigger is better

Sébastien F. Poget, Mark E. Girvin

Research output: Contribution to journalReview article

96 Scopus citations

Abstract

Considerable progress has been made recently on solution NMR studies of multi-transmembrane helix membrane protein systems of increasing size. Careful correlation of structure with function has validated the physiological relevance of these studies in detergent micelles. However, larger micelle and bicelle systems are sometimes required to stabilize the active forms of dynamic membrane proteins, such as the bacterial small multidrug resistance transporters. Even in these systems with aggregate molecular weights well over 100 kDa, solution NMR structural studies are feasible-but challenging.

Original languageEnglish (US)
Pages (from-to)3098-3106
Number of pages9
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1768
Issue number12
DOIs
StatePublished - Dec 1 2007

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Keywords

  • Bicelle
  • Micelle
  • Multidrug resistance
  • Smr
  • Structure

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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