Solute transport to the endothelial intercellular cleft

The effect of wall shear stress

Louis Hodgson, John M. Tarbell

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The interendothelial cleft is the major transport pathway across the endothelium for hydrophilic solutes including albumin and low density lipoprotein. Previous models of arterial wall transport have assumed that the entire endothelial cell surface is available for transport from the fluid (blood) phase. One of the consequence of a cleft-mediated solute uptake mechanism is the limited area available for mass transport. This effect, together with the influence of a predominantly longitudinal cleft orientation in relation to flow, dramatically alters the fluid-phase mass transport characteristics relative to what has been assumed previously in analyzing vascular solute uptake problems. We have used a finite element computational model to simulate fluid phase transport to a longitudinal endothelial cleft under realistic wall shear rate conditions. Our numerical results show reduced dependence of the mass transfer rate on the wall shear rate compared to the classical Leveque solution for mass transport in a cross-flow configuration and confirm the significance of the wall and not the fluid as the limiting resistance to transport of macromolecules.

Original languageEnglish (US)
Pages (from-to)936-945
Number of pages10
JournalAnnals of Biomedical Engineering
Volume30
Issue number7
DOIs
StatePublished - Jul 2002
Externally publishedYes

Fingerprint

Solute transport
Shear stress
Mass transfer
Fluids
Shear deformation
Lipoproteins
Endothelial cells
Macromolecules
Blood

Keywords

  • Atherosclerosis
  • Diffusion
  • Interendothelial junction
  • LDL

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Solute transport to the endothelial intercellular cleft : The effect of wall shear stress. / Hodgson, Louis; Tarbell, John M.

In: Annals of Biomedical Engineering, Vol. 30, No. 7, 07.2002, p. 936-945.

Research output: Contribution to journalArticle

@article{e2c9802a6c68471d92fa1fc63153a9b6,
title = "Solute transport to the endothelial intercellular cleft: The effect of wall shear stress",
abstract = "The interendothelial cleft is the major transport pathway across the endothelium for hydrophilic solutes including albumin and low density lipoprotein. Previous models of arterial wall transport have assumed that the entire endothelial cell surface is available for transport from the fluid (blood) phase. One of the consequence of a cleft-mediated solute uptake mechanism is the limited area available for mass transport. This effect, together with the influence of a predominantly longitudinal cleft orientation in relation to flow, dramatically alters the fluid-phase mass transport characteristics relative to what has been assumed previously in analyzing vascular solute uptake problems. We have used a finite element computational model to simulate fluid phase transport to a longitudinal endothelial cleft under realistic wall shear rate conditions. Our numerical results show reduced dependence of the mass transfer rate on the wall shear rate compared to the classical Leveque solution for mass transport in a cross-flow configuration and confirm the significance of the wall and not the fluid as the limiting resistance to transport of macromolecules.",
keywords = "Atherosclerosis, Diffusion, Interendothelial junction, LDL",
author = "Louis Hodgson and Tarbell, {John M.}",
year = "2002",
month = "7",
doi = "10.1114/1.1507846",
language = "English (US)",
volume = "30",
pages = "936--945",
journal = "Annals of Biomedical Engineering",
issn = "0090-6964",
publisher = "Springer Netherlands",
number = "7",

}

TY - JOUR

T1 - Solute transport to the endothelial intercellular cleft

T2 - The effect of wall shear stress

AU - Hodgson, Louis

AU - Tarbell, John M.

PY - 2002/7

Y1 - 2002/7

N2 - The interendothelial cleft is the major transport pathway across the endothelium for hydrophilic solutes including albumin and low density lipoprotein. Previous models of arterial wall transport have assumed that the entire endothelial cell surface is available for transport from the fluid (blood) phase. One of the consequence of a cleft-mediated solute uptake mechanism is the limited area available for mass transport. This effect, together with the influence of a predominantly longitudinal cleft orientation in relation to flow, dramatically alters the fluid-phase mass transport characteristics relative to what has been assumed previously in analyzing vascular solute uptake problems. We have used a finite element computational model to simulate fluid phase transport to a longitudinal endothelial cleft under realistic wall shear rate conditions. Our numerical results show reduced dependence of the mass transfer rate on the wall shear rate compared to the classical Leveque solution for mass transport in a cross-flow configuration and confirm the significance of the wall and not the fluid as the limiting resistance to transport of macromolecules.

AB - The interendothelial cleft is the major transport pathway across the endothelium for hydrophilic solutes including albumin and low density lipoprotein. Previous models of arterial wall transport have assumed that the entire endothelial cell surface is available for transport from the fluid (blood) phase. One of the consequence of a cleft-mediated solute uptake mechanism is the limited area available for mass transport. This effect, together with the influence of a predominantly longitudinal cleft orientation in relation to flow, dramatically alters the fluid-phase mass transport characteristics relative to what has been assumed previously in analyzing vascular solute uptake problems. We have used a finite element computational model to simulate fluid phase transport to a longitudinal endothelial cleft under realistic wall shear rate conditions. Our numerical results show reduced dependence of the mass transfer rate on the wall shear rate compared to the classical Leveque solution for mass transport in a cross-flow configuration and confirm the significance of the wall and not the fluid as the limiting resistance to transport of macromolecules.

KW - Atherosclerosis

KW - Diffusion

KW - Interendothelial junction

KW - LDL

UR - http://www.scopus.com/inward/record.url?scp=0036629472&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036629472&partnerID=8YFLogxK

U2 - 10.1114/1.1507846

DO - 10.1114/1.1507846

M3 - Article

VL - 30

SP - 936

EP - 945

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

SN - 0090-6964

IS - 7

ER -