Soluble levels of CD27 and CD30 are associated with risk of non-Hodgkin lymphoma in three Chinese prospective cohorts

Bryan A. Bassig, Xiao Ou Shu, Woon Puay Koh, Yu Tang Gao, Mark P. Purdue, Lesley M. Butler, Jennifer Adams-Haduch, Yong Bing Xiang, Troy J. Kemp, Renwei Wang, Ligia A. Pinto, Tongzhang Zheng, Bu Tian Ji, Howard D. Hosgood, Wei Hu, Gong Yang, Heping Zhang, Wong Ho Chow, Christopher Kim, Wei Jie Seow & 4 others Wei Zheng, Jian Min Yuan, Qing Lan, Nathaniel Rothman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Prospective studies conducted in Western populations have suggested that alterations in soluble CD27 (sCD27) and soluble CD30 (sCD30), two markers indicative of B-cell activation, are associated with risk of non-Hodgkin lymphoma (NHL). Given that the characteristics of NHL in East Asia differ from the West and mechanistic commonalities between these populations with respect to the role of intermediate endpoint biomarkers in lymphomagenesis have not been explored, we conducted a pooled nested case-control study from three prospective studies of Chinese men and women including 218 NHL cases and 218 individually matched controls. Compared with the lowest quartile, ORs (95% CIs) for the second, third and fourth quartiles of sCD27 were 1.60 (0.83-3.09), 1.94 (0.98-3.83) and 4.45 (2.25-8.81), respectively (p<inf>trend</inf> = 0.000005). The corresponding ORs for sCD30 were 1.74 (0.85-3.58), 1.86 (0.94-3.67) and 5.15 (2.62-10.12; p<inf>trend</inf> = 0.0000002). These associations remained statistically significant in individuals diagnosed with NHL 10 or more years after blood draw. Notably, the magnitude of the associations with NHL risk was very similar to those in Western populations in previous studies. These findings of the similar association between sCD27 or sCD30 and NHL risk across different populations support an important underlying mechanism of B-cell activation in lymphomagenesis. What's new? Risk of non-Hodgkin lymphoma (NHL) may be foreshadowed by elevated levels of soluble CD27 and CD30, markers reflective of chronic B-cell activation. These associations are based on evidence from Western populations, but the present study shows that alterations in soluble CD27 and CD30 are also linked to future NHL risk in Chinese men and women. As with individuals of European descent, in Asians the associations persisted for 10 or more years before NHL diagnosis. The data suggest that a common mechanism involving B-cell activation may underlie NHL development across populations, despite differences in NHL incidence and subtype distribution.

Original languageEnglish (US)
Pages (from-to)2688-2695
Number of pages8
JournalInternational Journal of Cancer
Volume137
Issue number11
DOIs
StatePublished - Dec 1 2015

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Non-Hodgkin's Lymphoma
B-Lymphocytes
Population
Prospective Studies
Far East
Case-Control Studies
Biomarkers
Incidence

Keywords

  • CD27
  • CD30
  • East Asians
  • immune markers
  • non-Hodgkin lymphoma
  • prospective study

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bassig, B. A., Shu, X. O., Koh, W. P., Gao, Y. T., Purdue, M. P., Butler, L. M., ... Rothman, N. (2015). Soluble levels of CD27 and CD30 are associated with risk of non-Hodgkin lymphoma in three Chinese prospective cohorts. International Journal of Cancer, 137(11), 2688-2695. https://doi.org/10.1002/ijc.29637

Soluble levels of CD27 and CD30 are associated with risk of non-Hodgkin lymphoma in three Chinese prospective cohorts. / Bassig, Bryan A.; Shu, Xiao Ou; Koh, Woon Puay; Gao, Yu Tang; Purdue, Mark P.; Butler, Lesley M.; Adams-Haduch, Jennifer; Xiang, Yong Bing; Kemp, Troy J.; Wang, Renwei; Pinto, Ligia A.; Zheng, Tongzhang; Ji, Bu Tian; Hosgood, Howard D.; Hu, Wei; Yang, Gong; Zhang, Heping; Chow, Wong Ho; Kim, Christopher; Seow, Wei Jie; Zheng, Wei; Yuan, Jian Min; Lan, Qing; Rothman, Nathaniel.

In: International Journal of Cancer, Vol. 137, No. 11, 01.12.2015, p. 2688-2695.

Research output: Contribution to journalArticle

Bassig, BA, Shu, XO, Koh, WP, Gao, YT, Purdue, MP, Butler, LM, Adams-Haduch, J, Xiang, YB, Kemp, TJ, Wang, R, Pinto, LA, Zheng, T, Ji, BT, Hosgood, HD, Hu, W, Yang, G, Zhang, H, Chow, WH, Kim, C, Seow, WJ, Zheng, W, Yuan, JM, Lan, Q & Rothman, N 2015, 'Soluble levels of CD27 and CD30 are associated with risk of non-Hodgkin lymphoma in three Chinese prospective cohorts', International Journal of Cancer, vol. 137, no. 11, pp. 2688-2695. https://doi.org/10.1002/ijc.29637
Bassig, Bryan A. ; Shu, Xiao Ou ; Koh, Woon Puay ; Gao, Yu Tang ; Purdue, Mark P. ; Butler, Lesley M. ; Adams-Haduch, Jennifer ; Xiang, Yong Bing ; Kemp, Troy J. ; Wang, Renwei ; Pinto, Ligia A. ; Zheng, Tongzhang ; Ji, Bu Tian ; Hosgood, Howard D. ; Hu, Wei ; Yang, Gong ; Zhang, Heping ; Chow, Wong Ho ; Kim, Christopher ; Seow, Wei Jie ; Zheng, Wei ; Yuan, Jian Min ; Lan, Qing ; Rothman, Nathaniel. / Soluble levels of CD27 and CD30 are associated with risk of non-Hodgkin lymphoma in three Chinese prospective cohorts. In: International Journal of Cancer. 2015 ; Vol. 137, No. 11. pp. 2688-2695.
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AU - Bassig, Bryan A.

AU - Shu, Xiao Ou

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AU - Gao, Yu Tang

AU - Purdue, Mark P.

AU - Butler, Lesley M.

AU - Adams-Haduch, Jennifer

AU - Xiang, Yong Bing

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AU - Wang, Renwei

AU - Pinto, Ligia A.

AU - Zheng, Tongzhang

AU - Ji, Bu Tian

AU - Hosgood, Howard D.

AU - Hu, Wei

AU - Yang, Gong

AU - Zhang, Heping

AU - Chow, Wong Ho

AU - Kim, Christopher

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AU - Zheng, Wei

AU - Yuan, Jian Min

AU - Lan, Qing

AU - Rothman, Nathaniel

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