Soluble E-selectin, soluble L-selectin and soluble ICAM-1 in bronchopulmonary dysplasia, and changes with dexamethasone

Praveen Ballabh, Jaishree Kumari, Alfred N. Krauss, Junghee J. Shin, Ajey Jain, Peter A M Auld, Martin L. Lesser, Susanna Cunningham-Rundles

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective. To evaluate longitudinal change in arterial blood plasma levels of soluble adhesion molecules in infants of <30 weeks' gestation with respiratory distress syndrome (RDS) and to look for differences in these levels in neonates who subsequently developed bronchopulmonary dysplasia (BPD) compared with those neonates who did not, and also to investigate the effect of dexamethasone treatment on levels of soluble adhesion molecules in plasma. Methods. We measured plasma concentrations of soluble L-selectin (sL-selectin), soluble E-selectin (sE-selectin), and soluble intercellular adhesion molecule-1 on days 1,3,7,14,21, and 28 of life and before and 2 to 3 days after initiating a 6-day course of dexamethasone treatment. Infants with RDS were followed until discharge and were classified as non-BPD and either 1) BPD day 28 reflecting oxygen requirement on day 28 but not at 36 corrected weeks or 2) BPD 36 weeks reflecting oxygen requirement at 36 (corrected) weeks' gestation. The classification of presence or absence of BPD by oxygen requirement was supported by and was consistent with radiologic findings of BPD for all infants. The difference between BPD day 28 and BPD 36 weeks was supported by more extensive radiologic effects in the latter. Results. The arterial plasma level of sL-selectin in infants who had RDS and did not develop BPD was significantly decreased compared with term healthy infants, as was the level of sE-selectin. Compared with infants who had RDS and did not develop BPD, sL-selectin levels were even further decreased in infants who had RDS and did develop BPD both at birth and throughout the first 4 weeks of life (day 1 through day 28). Infants with BPD also showed increasing levels of sE-selectin during this period of time, whereas infants without BPD did not. Levels of soluble intercellular adhesion molecule-1 in infants without BPD were not different from infants with BPD initially but increased in infants with BPD compared with infants without BPD, significant on day 28 in both groups. Dexamethasone treatment increased concentration of sL-selectin and decreased concentration of sE-selectin. Conclusions. Low sL-selectin may be an early indicator of enhanced risk for BPD. Low levels of sL-selectin and increasing levels of sE-selectin may be risk factors for BPD. The effects of dexamethasone treatment include significant modulation of adhesion molecules.

Original languageEnglish (US)
Pages (from-to)461-468
Number of pages8
JournalPediatrics
Volume111
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

Fingerprint

L-Selectin
Bronchopulmonary Dysplasia
E-Selectin
Intercellular Adhesion Molecule-1
Dexamethasone
Oxygen
Newborn Infant
Newborn Respiratory Distress Syndrome
Pregnancy
Birth Order

Keywords

  • Bronchopulmonary dysplasia
  • Dexamethasone
  • Soluble E-selectin
  • Soluble ICAM-1
  • Soluble L-selectin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Ballabh, P., Kumari, J., Krauss, A. N., Shin, J. J., Jain, A., Auld, P. A. M., ... Cunningham-Rundles, S. (2003). Soluble E-selectin, soluble L-selectin and soluble ICAM-1 in bronchopulmonary dysplasia, and changes with dexamethasone. Pediatrics, 111(3), 461-468. https://doi.org/10.1542/peds.111.3.461

Soluble E-selectin, soluble L-selectin and soluble ICAM-1 in bronchopulmonary dysplasia, and changes with dexamethasone. / Ballabh, Praveen; Kumari, Jaishree; Krauss, Alfred N.; Shin, Junghee J.; Jain, Ajey; Auld, Peter A M; Lesser, Martin L.; Cunningham-Rundles, Susanna.

In: Pediatrics, Vol. 111, No. 3, 01.03.2003, p. 461-468.

Research output: Contribution to journalArticle

Ballabh, P, Kumari, J, Krauss, AN, Shin, JJ, Jain, A, Auld, PAM, Lesser, ML & Cunningham-Rundles, S 2003, 'Soluble E-selectin, soluble L-selectin and soluble ICAM-1 in bronchopulmonary dysplasia, and changes with dexamethasone', Pediatrics, vol. 111, no. 3, pp. 461-468. https://doi.org/10.1542/peds.111.3.461
Ballabh, Praveen ; Kumari, Jaishree ; Krauss, Alfred N. ; Shin, Junghee J. ; Jain, Ajey ; Auld, Peter A M ; Lesser, Martin L. ; Cunningham-Rundles, Susanna. / Soluble E-selectin, soluble L-selectin and soluble ICAM-1 in bronchopulmonary dysplasia, and changes with dexamethasone. In: Pediatrics. 2003 ; Vol. 111, No. 3. pp. 461-468.
@article{0af4766bb2794ab2a0d32e2452b06c5b,
title = "Soluble E-selectin, soluble L-selectin and soluble ICAM-1 in bronchopulmonary dysplasia, and changes with dexamethasone",
abstract = "Objective. To evaluate longitudinal change in arterial blood plasma levels of soluble adhesion molecules in infants of <30 weeks' gestation with respiratory distress syndrome (RDS) and to look for differences in these levels in neonates who subsequently developed bronchopulmonary dysplasia (BPD) compared with those neonates who did not, and also to investigate the effect of dexamethasone treatment on levels of soluble adhesion molecules in plasma. Methods. We measured plasma concentrations of soluble L-selectin (sL-selectin), soluble E-selectin (sE-selectin), and soluble intercellular adhesion molecule-1 on days 1,3,7,14,21, and 28 of life and before and 2 to 3 days after initiating a 6-day course of dexamethasone treatment. Infants with RDS were followed until discharge and were classified as non-BPD and either 1) BPD day 28 reflecting oxygen requirement on day 28 but not at 36 corrected weeks or 2) BPD 36 weeks reflecting oxygen requirement at 36 (corrected) weeks' gestation. The classification of presence or absence of BPD by oxygen requirement was supported by and was consistent with radiologic findings of BPD for all infants. The difference between BPD day 28 and BPD 36 weeks was supported by more extensive radiologic effects in the latter. Results. The arterial plasma level of sL-selectin in infants who had RDS and did not develop BPD was significantly decreased compared with term healthy infants, as was the level of sE-selectin. Compared with infants who had RDS and did not develop BPD, sL-selectin levels were even further decreased in infants who had RDS and did develop BPD both at birth and throughout the first 4 weeks of life (day 1 through day 28). Infants with BPD also showed increasing levels of sE-selectin during this period of time, whereas infants without BPD did not. Levels of soluble intercellular adhesion molecule-1 in infants without BPD were not different from infants with BPD initially but increased in infants with BPD compared with infants without BPD, significant on day 28 in both groups. Dexamethasone treatment increased concentration of sL-selectin and decreased concentration of sE-selectin. Conclusions. Low sL-selectin may be an early indicator of enhanced risk for BPD. Low levels of sL-selectin and increasing levels of sE-selectin may be risk factors for BPD. The effects of dexamethasone treatment include significant modulation of adhesion molecules.",
keywords = "Bronchopulmonary dysplasia, Dexamethasone, Soluble E-selectin, Soluble ICAM-1, Soluble L-selectin",
author = "Praveen Ballabh and Jaishree Kumari and Krauss, {Alfred N.} and Shin, {Junghee J.} and Ajey Jain and Auld, {Peter A M} and Lesser, {Martin L.} and Susanna Cunningham-Rundles",
year = "2003",
month = "3",
day = "1",
doi = "10.1542/peds.111.3.461",
language = "English (US)",
volume = "111",
pages = "461--468",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "3",

}

TY - JOUR

T1 - Soluble E-selectin, soluble L-selectin and soluble ICAM-1 in bronchopulmonary dysplasia, and changes with dexamethasone

AU - Ballabh, Praveen

AU - Kumari, Jaishree

AU - Krauss, Alfred N.

AU - Shin, Junghee J.

AU - Jain, Ajey

AU - Auld, Peter A M

AU - Lesser, Martin L.

AU - Cunningham-Rundles, Susanna

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Objective. To evaluate longitudinal change in arterial blood plasma levels of soluble adhesion molecules in infants of <30 weeks' gestation with respiratory distress syndrome (RDS) and to look for differences in these levels in neonates who subsequently developed bronchopulmonary dysplasia (BPD) compared with those neonates who did not, and also to investigate the effect of dexamethasone treatment on levels of soluble adhesion molecules in plasma. Methods. We measured plasma concentrations of soluble L-selectin (sL-selectin), soluble E-selectin (sE-selectin), and soluble intercellular adhesion molecule-1 on days 1,3,7,14,21, and 28 of life and before and 2 to 3 days after initiating a 6-day course of dexamethasone treatment. Infants with RDS were followed until discharge and were classified as non-BPD and either 1) BPD day 28 reflecting oxygen requirement on day 28 but not at 36 corrected weeks or 2) BPD 36 weeks reflecting oxygen requirement at 36 (corrected) weeks' gestation. The classification of presence or absence of BPD by oxygen requirement was supported by and was consistent with radiologic findings of BPD for all infants. The difference between BPD day 28 and BPD 36 weeks was supported by more extensive radiologic effects in the latter. Results. The arterial plasma level of sL-selectin in infants who had RDS and did not develop BPD was significantly decreased compared with term healthy infants, as was the level of sE-selectin. Compared with infants who had RDS and did not develop BPD, sL-selectin levels were even further decreased in infants who had RDS and did develop BPD both at birth and throughout the first 4 weeks of life (day 1 through day 28). Infants with BPD also showed increasing levels of sE-selectin during this period of time, whereas infants without BPD did not. Levels of soluble intercellular adhesion molecule-1 in infants without BPD were not different from infants with BPD initially but increased in infants with BPD compared with infants without BPD, significant on day 28 in both groups. Dexamethasone treatment increased concentration of sL-selectin and decreased concentration of sE-selectin. Conclusions. Low sL-selectin may be an early indicator of enhanced risk for BPD. Low levels of sL-selectin and increasing levels of sE-selectin may be risk factors for BPD. The effects of dexamethasone treatment include significant modulation of adhesion molecules.

AB - Objective. To evaluate longitudinal change in arterial blood plasma levels of soluble adhesion molecules in infants of <30 weeks' gestation with respiratory distress syndrome (RDS) and to look for differences in these levels in neonates who subsequently developed bronchopulmonary dysplasia (BPD) compared with those neonates who did not, and also to investigate the effect of dexamethasone treatment on levels of soluble adhesion molecules in plasma. Methods. We measured plasma concentrations of soluble L-selectin (sL-selectin), soluble E-selectin (sE-selectin), and soluble intercellular adhesion molecule-1 on days 1,3,7,14,21, and 28 of life and before and 2 to 3 days after initiating a 6-day course of dexamethasone treatment. Infants with RDS were followed until discharge and were classified as non-BPD and either 1) BPD day 28 reflecting oxygen requirement on day 28 but not at 36 corrected weeks or 2) BPD 36 weeks reflecting oxygen requirement at 36 (corrected) weeks' gestation. The classification of presence or absence of BPD by oxygen requirement was supported by and was consistent with radiologic findings of BPD for all infants. The difference between BPD day 28 and BPD 36 weeks was supported by more extensive radiologic effects in the latter. Results. The arterial plasma level of sL-selectin in infants who had RDS and did not develop BPD was significantly decreased compared with term healthy infants, as was the level of sE-selectin. Compared with infants who had RDS and did not develop BPD, sL-selectin levels were even further decreased in infants who had RDS and did develop BPD both at birth and throughout the first 4 weeks of life (day 1 through day 28). Infants with BPD also showed increasing levels of sE-selectin during this period of time, whereas infants without BPD did not. Levels of soluble intercellular adhesion molecule-1 in infants without BPD were not different from infants with BPD initially but increased in infants with BPD compared with infants without BPD, significant on day 28 in both groups. Dexamethasone treatment increased concentration of sL-selectin and decreased concentration of sE-selectin. Conclusions. Low sL-selectin may be an early indicator of enhanced risk for BPD. Low levels of sL-selectin and increasing levels of sE-selectin may be risk factors for BPD. The effects of dexamethasone treatment include significant modulation of adhesion molecules.

KW - Bronchopulmonary dysplasia

KW - Dexamethasone

KW - Soluble E-selectin

KW - Soluble ICAM-1

KW - Soluble L-selectin

UR - http://www.scopus.com/inward/record.url?scp=0344754092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344754092&partnerID=8YFLogxK

U2 - 10.1542/peds.111.3.461

DO - 10.1542/peds.111.3.461

M3 - Article

VL - 111

SP - 461

EP - 468

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 3

ER -