TY - JOUR
T1 - Sodium polystyrene sulfonate (SPS)
T2 - Sorbitol-induced colonic necrosis
AU - Erfani, Mohamad
AU - Akula, Yougandhar
AU - Zolfaghari, Touraj
AU - Hertan, Hilary I.
PY - 2010/11
Y1 - 2010/11
N2 - Sodium polystyrene sulfonate (SPS) is a cation exchange resin which primarily acts in the colon. It is usually administered with an osmotic laxative (e.g. sorbitol), orally or as a retention enema, to treat hyperkalemia. SPS-sorbitol use has been implicated in damage to different parts of the gastrointestinal (GI) tract. Adverse GI reactions include anorexia, nausea, vomiting, constipation, fecal impaction, intestinal obstruction and intestinal necrosis (rare). We present an uncommon case of ulceration with necrosis of the ascending colon following multiple oral SPS-sorbitol administrations.
AB - Sodium polystyrene sulfonate (SPS) is a cation exchange resin which primarily acts in the colon. It is usually administered with an osmotic laxative (e.g. sorbitol), orally or as a retention enema, to treat hyperkalemia. SPS-sorbitol use has been implicated in damage to different parts of the gastrointestinal (GI) tract. Adverse GI reactions include anorexia, nausea, vomiting, constipation, fecal impaction, intestinal obstruction and intestinal necrosis (rare). We present an uncommon case of ulceration with necrosis of the ascending colon following multiple oral SPS-sorbitol administrations.
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M3 - Article
AN - SCOPUS:79551706704
SN - 0277-4208
VL - 34
SP - 47
EP - 50
JO - Practical Gastroenterology
JF - Practical Gastroenterology
IS - 11
ER -