SNPs and haplotypes in the S100B gene reveal association with schizophrenia

Jixia Liu, Yongyong Shi, Junxia Tang, Tingwei Guo, Xiuxia Li, Yifeng Yang, Qingying Chen, Xinzhi Zhao, Guang He, Guoyin Feng, Niufan Gu, Shaomin Zhu, Huijun Liu, Lin He

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The S100B gene locates in 21q22.3 and produces neurotrophin mainly in astrocytes of CNS which can act as an extensive marker of glial cell integrity. The synaptic destabilization hypothesis (GGF/SD) suggests that the functional deficiency of growth factors like S100B is involved in the etiology of schizophrenia and the S100B serum concentration is reported to be significantly increased in patients with acute schizophrenia and decreased in chronic schizophrenia patients. To validate the association between S100B and schizophrenia, 384 cases and 401 controls, all Chinese Han subjects, were recruited. Four SNPs V1 (-960C > G), V2 (-111C > T), V3 (2757C > G, rs1051169), and V4 (5748C > T, rs9722) were studied. And haplotype V3-V4 (G-C) showed a significant association with schizophrenia. Our study showed an association between schizophrenia and a possible susceptible haplotype V3-V4 (G-C) which possesses a genetic tendency for increased S100B expression. Our results suggest that S100B could be a susceptible gene for schizophrenia and provide indirect evidence for the GGF/SD hypothesis.

Original languageEnglish (US)
Pages (from-to)335-341
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume328
Issue number1
DOIs
StatePublished - Mar 4 2005
Externally publishedYes

Fingerprint

Haplotypes
Single Nucleotide Polymorphism
Schizophrenia
Genes
Nerve Growth Factors
Intercellular Signaling Peptides and Proteins
Neuroglia
Astrocytes
Serum

Keywords

  • Association
  • Growth factors' deficiency and synaptic destabilization hypothesis of schizophrenia
  • Haplotype
  • Linkage disequilibrium
  • S100B
  • Sp1

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

SNPs and haplotypes in the S100B gene reveal association with schizophrenia. / Liu, Jixia; Shi, Yongyong; Tang, Junxia; Guo, Tingwei; Li, Xiuxia; Yang, Yifeng; Chen, Qingying; Zhao, Xinzhi; He, Guang; Feng, Guoyin; Gu, Niufan; Zhu, Shaomin; Liu, Huijun; He, Lin.

In: Biochemical and Biophysical Research Communications, Vol. 328, No. 1, 04.03.2005, p. 335-341.

Research output: Contribution to journalArticle

Liu, J, Shi, Y, Tang, J, Guo, T, Li, X, Yang, Y, Chen, Q, Zhao, X, He, G, Feng, G, Gu, N, Zhu, S, Liu, H & He, L 2005, 'SNPs and haplotypes in the S100B gene reveal association with schizophrenia', Biochemical and Biophysical Research Communications, vol. 328, no. 1, pp. 335-341. https://doi.org/10.1016/j.bbrc.2004.12.175
Liu, Jixia ; Shi, Yongyong ; Tang, Junxia ; Guo, Tingwei ; Li, Xiuxia ; Yang, Yifeng ; Chen, Qingying ; Zhao, Xinzhi ; He, Guang ; Feng, Guoyin ; Gu, Niufan ; Zhu, Shaomin ; Liu, Huijun ; He, Lin. / SNPs and haplotypes in the S100B gene reveal association with schizophrenia. In: Biochemical and Biophysical Research Communications. 2005 ; Vol. 328, No. 1. pp. 335-341.
@article{d33de9a204384b50b105fb17cb169e16,
title = "SNPs and haplotypes in the S100B gene reveal association with schizophrenia",
abstract = "The S100B gene locates in 21q22.3 and produces neurotrophin mainly in astrocytes of CNS which can act as an extensive marker of glial cell integrity. The synaptic destabilization hypothesis (GGF/SD) suggests that the functional deficiency of growth factors like S100B is involved in the etiology of schizophrenia and the S100B serum concentration is reported to be significantly increased in patients with acute schizophrenia and decreased in chronic schizophrenia patients. To validate the association between S100B and schizophrenia, 384 cases and 401 controls, all Chinese Han subjects, were recruited. Four SNPs V1 (-960C > G), V2 (-111C > T), V3 (2757C > G, rs1051169), and V4 (5748C > T, rs9722) were studied. And haplotype V3-V4 (G-C) showed a significant association with schizophrenia. Our study showed an association between schizophrenia and a possible susceptible haplotype V3-V4 (G-C) which possesses a genetic tendency for increased S100B expression. Our results suggest that S100B could be a susceptible gene for schizophrenia and provide indirect evidence for the GGF/SD hypothesis.",
keywords = "Association, Growth factors' deficiency and synaptic destabilization hypothesis of schizophrenia, Haplotype, Linkage disequilibrium, S100B, Sp1",
author = "Jixia Liu and Yongyong Shi and Junxia Tang and Tingwei Guo and Xiuxia Li and Yifeng Yang and Qingying Chen and Xinzhi Zhao and Guang He and Guoyin Feng and Niufan Gu and Shaomin Zhu and Huijun Liu and Lin He",
year = "2005",
month = "3",
day = "4",
doi = "10.1016/j.bbrc.2004.12.175",
language = "English (US)",
volume = "328",
pages = "335--341",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - SNPs and haplotypes in the S100B gene reveal association with schizophrenia

AU - Liu, Jixia

AU - Shi, Yongyong

AU - Tang, Junxia

AU - Guo, Tingwei

AU - Li, Xiuxia

AU - Yang, Yifeng

AU - Chen, Qingying

AU - Zhao, Xinzhi

AU - He, Guang

AU - Feng, Guoyin

AU - Gu, Niufan

AU - Zhu, Shaomin

AU - Liu, Huijun

AU - He, Lin

PY - 2005/3/4

Y1 - 2005/3/4

N2 - The S100B gene locates in 21q22.3 and produces neurotrophin mainly in astrocytes of CNS which can act as an extensive marker of glial cell integrity. The synaptic destabilization hypothesis (GGF/SD) suggests that the functional deficiency of growth factors like S100B is involved in the etiology of schizophrenia and the S100B serum concentration is reported to be significantly increased in patients with acute schizophrenia and decreased in chronic schizophrenia patients. To validate the association between S100B and schizophrenia, 384 cases and 401 controls, all Chinese Han subjects, were recruited. Four SNPs V1 (-960C > G), V2 (-111C > T), V3 (2757C > G, rs1051169), and V4 (5748C > T, rs9722) were studied. And haplotype V3-V4 (G-C) showed a significant association with schizophrenia. Our study showed an association between schizophrenia and a possible susceptible haplotype V3-V4 (G-C) which possesses a genetic tendency for increased S100B expression. Our results suggest that S100B could be a susceptible gene for schizophrenia and provide indirect evidence for the GGF/SD hypothesis.

AB - The S100B gene locates in 21q22.3 and produces neurotrophin mainly in astrocytes of CNS which can act as an extensive marker of glial cell integrity. The synaptic destabilization hypothesis (GGF/SD) suggests that the functional deficiency of growth factors like S100B is involved in the etiology of schizophrenia and the S100B serum concentration is reported to be significantly increased in patients with acute schizophrenia and decreased in chronic schizophrenia patients. To validate the association between S100B and schizophrenia, 384 cases and 401 controls, all Chinese Han subjects, were recruited. Four SNPs V1 (-960C > G), V2 (-111C > T), V3 (2757C > G, rs1051169), and V4 (5748C > T, rs9722) were studied. And haplotype V3-V4 (G-C) showed a significant association with schizophrenia. Our study showed an association between schizophrenia and a possible susceptible haplotype V3-V4 (G-C) which possesses a genetic tendency for increased S100B expression. Our results suggest that S100B could be a susceptible gene for schizophrenia and provide indirect evidence for the GGF/SD hypothesis.

KW - Association

KW - Growth factors' deficiency and synaptic destabilization hypothesis of schizophrenia

KW - Haplotype

KW - Linkage disequilibrium

KW - S100B

KW - Sp1

UR - http://www.scopus.com/inward/record.url?scp=19944432629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19944432629&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2004.12.175

DO - 10.1016/j.bbrc.2004.12.175

M3 - Article

C2 - 15670788

AN - SCOPUS:19944432629

VL - 328

SP - 335

EP - 341

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 1

ER -