@article{e3ad7b1eb6984ca1a9a4b5c9df108107,
title = "Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression",
abstract = "Wei et al. found that Snai2 is preferentially expressed and required in bone marrow mesenchymal stem and progenitor cells (MSPCs) for their maintenance and regeneration. The authors show that Snai2 promotes self-renewal by suppressing Spp1 expression in MSPCs.",
keywords = "Snai2/Slug, bone marrow, hematopoietic stem cell niche, mesenchymal stem and progenitor cells, osteopontin/Spp1, self-renewal, stromal cells, transcriptional regulation",
author = "Qiaozhi Wei and Fumio Nakahara and Noboru Asada and Dachuan Zhang and Xin Gao and Chunliang Xu and Alan Alfieri and Brodin, {N. Patrik} and Zimmerman, {Samuel E.} and Mar, {Jessica C.} and Chandan Guha and Wenjun Guo and Frenette, {Paul S.}",
note = "Funding Information: We thank the National Institutes of Health (DK056638, HL069438, and HL116340), the Leukemia and Lymphoma Society (LLS-TRP 6475-15), and the New York State Department of Health (NYSTEM IIRP C029570 and The Einstein Training Program in Stem Cell Research, C34874GG) for their support of our laboratory. We also thank Y. Zhang of the Albert Einstein College of Medicine Gene Targeting and Transgenic Core, L. Tesfa of the Flow Cytometry Sorting Facility, R. Sellers of the Histology and Comparative Pathology Facility for technical assistance and guidance, and Dr. Luis Cardoso at City College of New York for micro-CT analyses. Q.W. performed most of the experiments, analyzed data, and wrote the manuscript. F.N. contributed to multiple in vitro assays and preliminary studies. N.A. helped analyzing the Snai2YFP; Ng2-Cre; R26-tdTomato mice. D.Z. and X.G. helped with mouse treatments and analysis. C.X. helped with MSPC differentiation assays. A.A. N.P.B. and C.G. performed the targeted limb irradiation. S.E.Z. and J.C.M. helped with RNA-seq analysis. W.G. contributed to the experimental design and manuscript. P.S.F. supervised the study and wrote the manuscript. All authors discussed the results and contributed to the manuscript. P.S.F. has served as consultant for Pfizer, received research funding from Ironwood Pharmaceuticals, and owns stock options of Cygnal Therapeutics. Funding Information: We thank the National Institutes of Health ( DK056638 , HL069438 , and HL116340 ), the Leukemia and Lymphoma Society (LLS- TRP 6475-15 ), and the New York State Department of Health (NYSTEM IIRP C029570 and The Einstein Training Program in Stem Cell Research , C34874GG ) for their support of our laboratory. We also thank Y. Zhang of the Albert Einstein College of Medicine Gene Targeting and Transgenic Core, L. Tesfa of the Flow Cytometry Sorting Facility, R. Sellers of the Histology and Comparative Pathology Facility for technical assistance and guidance, and Dr. Luis Cardoso at City College of New York for micro-CT analyses. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = jun,
day = "8",
doi = "10.1016/j.devcel.2020.04.012",
language = "English (US)",
volume = "53",
pages = "503--513.e5",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "5",
}