Smoking patterns and chronic kidney disease in US Hispanics: Hispanic Community Health Study/Study of Latinos

Nora Franceschini, Yu Deng, Michael F. Flessner, John H. Eckfeldt, Holly J. Kramer, James P. Lash, David J. Lee, Michal L. Melamed, Ashley E. Moncrieft, Ana C. Ricardo, Sylvia E. Rosas, Robert C. Kaplan, Leopoldo Raij, Jianwen Cai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BackgroundIntermittent smoking is prevalent among Hispanics, but little is known about whether this smoking pattern associates with increased chronic kidney disease (CKD) risk in this population. The objective of the present study is to identify patterns of exposure associated with CKD in US Hispanics. MethodsWe used cross-sectional data on 15 410 participants of the Hispanics Community Health Study/the Study of Latinos, a population-based study of individuals aged 18-74 years, recruited in 2008 to 2011 from four US field centers (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA). Smoking exposure was obtained through a questionnaire. CKD was defined by an estimated glomerular filtration rate of <60 mL/min/1.73 m2 or a urine albumin-to-creatinine ratio of ≥30 mg/g. ResultsApproximately 14% of individuals were daily and 7% were intermittent smokers, and 16% were past smokers. There was a significant interaction between smoking status and pack-years of exposure (P = 0.0003). In adjusted models, there was an increased odds of CKD among daily, intermittent and past smokers by pack-years compared with never smokers. The association of intermittent smokers was significant at 10 pack-years [odds ratio (OR) = 1.38, 95% confidence intervals (CI) 1.06, 1.81], whereas for daily smokers this association was observed at 40 pack-years (OR = 1.43, 95% CI 1.09, 1.89). ConclusionsOur findings of increased risk of CKD among Hispanics who are intermittent smokers support screening and smoking cessation interventions targeted to this population for the prevention of CKD. It also suggests novel mechanistic pathways for kidney toxicity that should be further explored in future studies.

Original languageEnglish (US)
Pages (from-to)1670-1676
Number of pages7
JournalNephrology Dialysis Transplantation
Volume31
Issue number10
DOIs
StatePublished - Oct 1 2016

Fingerprint

Chronic Renal Insufficiency
Hispanic Americans
Smoking
Health
Odds Ratio
Confidence Intervals
Population
Smoking Cessation
Glomerular Filtration Rate
Albumins
Creatinine
Urine
Kidney

Keywords

  • chronic kidney disease
  • Hispanics/Latinos
  • intermittent smoking

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Franceschini, N., Deng, Y., Flessner, M. F., Eckfeldt, J. H., Kramer, H. J., Lash, J. P., ... Cai, J. (2016). Smoking patterns and chronic kidney disease in US Hispanics: Hispanic Community Health Study/Study of Latinos. Nephrology Dialysis Transplantation, 31(10), 1670-1676. https://doi.org/10.1093/ndt/gfw210

Smoking patterns and chronic kidney disease in US Hispanics : Hispanic Community Health Study/Study of Latinos. / Franceschini, Nora; Deng, Yu; Flessner, Michael F.; Eckfeldt, John H.; Kramer, Holly J.; Lash, James P.; Lee, David J.; Melamed, Michal L.; Moncrieft, Ashley E.; Ricardo, Ana C.; Rosas, Sylvia E.; Kaplan, Robert C.; Raij, Leopoldo; Cai, Jianwen.

In: Nephrology Dialysis Transplantation, Vol. 31, No. 10, 01.10.2016, p. 1670-1676.

Research output: Contribution to journalArticle

Franceschini, N, Deng, Y, Flessner, MF, Eckfeldt, JH, Kramer, HJ, Lash, JP, Lee, DJ, Melamed, ML, Moncrieft, AE, Ricardo, AC, Rosas, SE, Kaplan, RC, Raij, L & Cai, J 2016, 'Smoking patterns and chronic kidney disease in US Hispanics: Hispanic Community Health Study/Study of Latinos', Nephrology Dialysis Transplantation, vol. 31, no. 10, pp. 1670-1676. https://doi.org/10.1093/ndt/gfw210
Franceschini, Nora ; Deng, Yu ; Flessner, Michael F. ; Eckfeldt, John H. ; Kramer, Holly J. ; Lash, James P. ; Lee, David J. ; Melamed, Michal L. ; Moncrieft, Ashley E. ; Ricardo, Ana C. ; Rosas, Sylvia E. ; Kaplan, Robert C. ; Raij, Leopoldo ; Cai, Jianwen. / Smoking patterns and chronic kidney disease in US Hispanics : Hispanic Community Health Study/Study of Latinos. In: Nephrology Dialysis Transplantation. 2016 ; Vol. 31, No. 10. pp. 1670-1676.
@article{c83eb082f06a492da7d75881ac37cf3b,
title = "Smoking patterns and chronic kidney disease in US Hispanics: Hispanic Community Health Study/Study of Latinos",
abstract = "BackgroundIntermittent smoking is prevalent among Hispanics, but little is known about whether this smoking pattern associates with increased chronic kidney disease (CKD) risk in this population. The objective of the present study is to identify patterns of exposure associated with CKD in US Hispanics. MethodsWe used cross-sectional data on 15 410 participants of the Hispanics Community Health Study/the Study of Latinos, a population-based study of individuals aged 18-74 years, recruited in 2008 to 2011 from four US field centers (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA). Smoking exposure was obtained through a questionnaire. CKD was defined by an estimated glomerular filtration rate of <60 mL/min/1.73 m2 or a urine albumin-to-creatinine ratio of ≥30 mg/g. ResultsApproximately 14{\%} of individuals were daily and 7{\%} were intermittent smokers, and 16{\%} were past smokers. There was a significant interaction between smoking status and pack-years of exposure (P = 0.0003). In adjusted models, there was an increased odds of CKD among daily, intermittent and past smokers by pack-years compared with never smokers. The association of intermittent smokers was significant at 10 pack-years [odds ratio (OR) = 1.38, 95{\%} confidence intervals (CI) 1.06, 1.81], whereas for daily smokers this association was observed at 40 pack-years (OR = 1.43, 95{\%} CI 1.09, 1.89). ConclusionsOur findings of increased risk of CKD among Hispanics who are intermittent smokers support screening and smoking cessation interventions targeted to this population for the prevention of CKD. It also suggests novel mechanistic pathways for kidney toxicity that should be further explored in future studies.",
keywords = "chronic kidney disease, Hispanics/Latinos, intermittent smoking",
author = "Nora Franceschini and Yu Deng and Flessner, {Michael F.} and Eckfeldt, {John H.} and Kramer, {Holly J.} and Lash, {James P.} and Lee, {David J.} and Melamed, {Michal L.} and Moncrieft, {Ashley E.} and Ricardo, {Ana C.} and Rosas, {Sylvia E.} and Kaplan, {Robert C.} and Leopoldo Raij and Jianwen Cai",
year = "2016",
month = "10",
day = "1",
doi = "10.1093/ndt/gfw210",
language = "English (US)",
volume = "31",
pages = "1670--1676",
journal = "Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Smoking patterns and chronic kidney disease in US Hispanics

T2 - Hispanic Community Health Study/Study of Latinos

AU - Franceschini, Nora

AU - Deng, Yu

AU - Flessner, Michael F.

AU - Eckfeldt, John H.

AU - Kramer, Holly J.

AU - Lash, James P.

AU - Lee, David J.

AU - Melamed, Michal L.

AU - Moncrieft, Ashley E.

AU - Ricardo, Ana C.

AU - Rosas, Sylvia E.

AU - Kaplan, Robert C.

AU - Raij, Leopoldo

AU - Cai, Jianwen

PY - 2016/10/1

Y1 - 2016/10/1

N2 - BackgroundIntermittent smoking is prevalent among Hispanics, but little is known about whether this smoking pattern associates with increased chronic kidney disease (CKD) risk in this population. The objective of the present study is to identify patterns of exposure associated with CKD in US Hispanics. MethodsWe used cross-sectional data on 15 410 participants of the Hispanics Community Health Study/the Study of Latinos, a population-based study of individuals aged 18-74 years, recruited in 2008 to 2011 from four US field centers (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA). Smoking exposure was obtained through a questionnaire. CKD was defined by an estimated glomerular filtration rate of <60 mL/min/1.73 m2 or a urine albumin-to-creatinine ratio of ≥30 mg/g. ResultsApproximately 14% of individuals were daily and 7% were intermittent smokers, and 16% were past smokers. There was a significant interaction between smoking status and pack-years of exposure (P = 0.0003). In adjusted models, there was an increased odds of CKD among daily, intermittent and past smokers by pack-years compared with never smokers. The association of intermittent smokers was significant at 10 pack-years [odds ratio (OR) = 1.38, 95% confidence intervals (CI) 1.06, 1.81], whereas for daily smokers this association was observed at 40 pack-years (OR = 1.43, 95% CI 1.09, 1.89). ConclusionsOur findings of increased risk of CKD among Hispanics who are intermittent smokers support screening and smoking cessation interventions targeted to this population for the prevention of CKD. It also suggests novel mechanistic pathways for kidney toxicity that should be further explored in future studies.

AB - BackgroundIntermittent smoking is prevalent among Hispanics, but little is known about whether this smoking pattern associates with increased chronic kidney disease (CKD) risk in this population. The objective of the present study is to identify patterns of exposure associated with CKD in US Hispanics. MethodsWe used cross-sectional data on 15 410 participants of the Hispanics Community Health Study/the Study of Latinos, a population-based study of individuals aged 18-74 years, recruited in 2008 to 2011 from four US field centers (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA). Smoking exposure was obtained through a questionnaire. CKD was defined by an estimated glomerular filtration rate of <60 mL/min/1.73 m2 or a urine albumin-to-creatinine ratio of ≥30 mg/g. ResultsApproximately 14% of individuals were daily and 7% were intermittent smokers, and 16% were past smokers. There was a significant interaction between smoking status and pack-years of exposure (P = 0.0003). In adjusted models, there was an increased odds of CKD among daily, intermittent and past smokers by pack-years compared with never smokers. The association of intermittent smokers was significant at 10 pack-years [odds ratio (OR) = 1.38, 95% confidence intervals (CI) 1.06, 1.81], whereas for daily smokers this association was observed at 40 pack-years (OR = 1.43, 95% CI 1.09, 1.89). ConclusionsOur findings of increased risk of CKD among Hispanics who are intermittent smokers support screening and smoking cessation interventions targeted to this population for the prevention of CKD. It also suggests novel mechanistic pathways for kidney toxicity that should be further explored in future studies.

KW - chronic kidney disease

KW - Hispanics/Latinos

KW - intermittent smoking

UR - http://www.scopus.com/inward/record.url?scp=84994802292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994802292&partnerID=8YFLogxK

U2 - 10.1093/ndt/gfw210

DO - 10.1093/ndt/gfw210

M3 - Article

C2 - 27257272

AN - SCOPUS:84994802292

VL - 31

SP - 1670

EP - 1676

JO - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

SN - 0931-0509

IS - 10

ER -