Smoking and DNA methylation: Correlation of methylation with smoking behavior and association with diseases and fetus development following prenatal exposure

Domniki Fragou; Eleni Pakkidi; Michael Aschner; Victoria Samanidou; Leda Kovatsi

doi:10.1016/j.fct.2019.04.059

Smoking and DNA methylation: Correlation of methylation with smoking behavior and association with diseases and fetus development following prenatal exposure

Domniki Fragou, Eleni Pakkidi, Michael Aschner, Victoria Samanidou, Leda Kovatsi

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Among epigenetic mechanisms, DNA methylation has been widely studied with respect to many environmental factors. Smoking is a common factor which affects both global and gene-specific DNA methylation. It is supported that smoking directly affects DNA methylation, and these effects contribute to the development and progression of various diseases, such as cancer, lung and cardiovascular diseases and male infertility. In addition, prenatal smoking influences the normal development of the fetus via DNA methylation changes. The DNA methylation profile and its smoking-induced alterations helps to distinguish current from former smokers and non-smokers and can be used to predict the risk for the development of a disease. This review summarizes the DNA methylation changes induced by smoking, their correlation with smoking behavior and their association with various diseases and fetus development.

Original language	English (US)
Pages (from-to)	312-327
Number of pages	16
Journal	Food and Chemical Toxicology
Volume	129
DOIs	https://doi.org/10.1016/j.fct.2019.04.059
State	Published - Jul 2019

Keywords

Cancer
DNA methylation
Epigenetics
Prenatal smoke exposure
Smoking

ASJC Scopus subject areas

Food Science
Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fct.2019.04.059

Cite this

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title = "Smoking and DNA methylation: Correlation of methylation with smoking behavior and association with diseases and fetus development following prenatal exposure",

abstract = "Among epigenetic mechanisms, DNA methylation has been widely studied with respect to many environmental factors. Smoking is a common factor which affects both global and gene-specific DNA methylation. It is supported that smoking directly affects DNA methylation, and these effects contribute to the development and progression of various diseases, such as cancer, lung and cardiovascular diseases and male infertility. In addition, prenatal smoking influences the normal development of the fetus via DNA methylation changes. The DNA methylation profile and its smoking-induced alterations helps to distinguish current from former smokers and non-smokers and can be used to predict the risk for the development of a disease. This review summarizes the DNA methylation changes induced by smoking, their correlation with smoking behavior and their association with various diseases and fetus development.",

keywords = "Cancer, DNA methylation, Epigenetics, Prenatal smoke exposure, Smoking",

author = "Domniki Fragou and Eleni Pakkidi and Michael Aschner and Victoria Samanidou and Leda Kovatsi",

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year = "2019",

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doi = "10.1016/j.fct.2019.04.059",

language = "English (US)",

volume = "129",

pages = "312--327",

journal = "Food and Chemical Toxicology",

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TY - JOUR

T1 - Smoking and DNA methylation

T2 - Correlation of methylation with smoking behavior and association with diseases and fetus development following prenatal exposure

AU - Fragou, Domniki

AU - Pakkidi, Eleni

AU - Aschner, Michael

AU - Samanidou, Victoria

AU - Kovatsi, Leda

PY - 2019/7

Y1 - 2019/7

N2 - Among epigenetic mechanisms, DNA methylation has been widely studied with respect to many environmental factors. Smoking is a common factor which affects both global and gene-specific DNA methylation. It is supported that smoking directly affects DNA methylation, and these effects contribute to the development and progression of various diseases, such as cancer, lung and cardiovascular diseases and male infertility. In addition, prenatal smoking influences the normal development of the fetus via DNA methylation changes. The DNA methylation profile and its smoking-induced alterations helps to distinguish current from former smokers and non-smokers and can be used to predict the risk for the development of a disease. This review summarizes the DNA methylation changes induced by smoking, their correlation with smoking behavior and their association with various diseases and fetus development.

AB - Among epigenetic mechanisms, DNA methylation has been widely studied with respect to many environmental factors. Smoking is a common factor which affects both global and gene-specific DNA methylation. It is supported that smoking directly affects DNA methylation, and these effects contribute to the development and progression of various diseases, such as cancer, lung and cardiovascular diseases and male infertility. In addition, prenatal smoking influences the normal development of the fetus via DNA methylation changes. The DNA methylation profile and its smoking-induced alterations helps to distinguish current from former smokers and non-smokers and can be used to predict the risk for the development of a disease. This review summarizes the DNA methylation changes induced by smoking, their correlation with smoking behavior and their association with various diseases and fetus development.

KW - Cancer

KW - DNA methylation

KW - Epigenetics

KW - Prenatal smoke exposure

KW - Smoking

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DO - 10.1016/j.fct.2019.04.059

M3 - Review article

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SN - 0278-6915

VL - 129

SP - 312

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JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

ER -

Smoking and DNA methylation: Correlation of methylation with smoking behavior and association with diseases and fetus development following prenatal exposure

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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