Smoking and DNA methylation: Correlation of methylation with smoking behavior and association with diseases and fetus development following prenatal exposure

Domniki Fragou, Eleni Pakkidi, Michael Aschner, Victoria Samanidou, Leda Kovatsi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Among epigenetic mechanisms, DNA methylation has been widely studied with respect to many environmental factors. Smoking is a common factor which affects both global and gene-specific DNA methylation. It is supported that smoking directly affects DNA methylation, and these effects contribute to the development and progression of various diseases, such as cancer, lung and cardiovascular diseases and male infertility. In addition, prenatal smoking influences the normal development of the fetus via DNA methylation changes. The DNA methylation profile and its smoking-induced alterations helps to distinguish current from former smokers and non-smokers and can be used to predict the risk for the development of a disease. This review summarizes the DNA methylation changes induced by smoking, their correlation with smoking behavior and their association with various diseases and fetus development.

Original languageEnglish (US)
Pages (from-to)312-327
Number of pages16
JournalFood and Chemical Toxicology
Volume129
DOIs
StatePublished - Jul 1 2019

Fingerprint

prenatal development
Methylation
DNA methylation
DNA Methylation
methylation
fetus
Fetus
Smoking
Association reactions
Male Infertility
male fertility
disease course
Epigenomics
epigenetics
respiratory tract diseases
cardiovascular diseases
Lung Diseases
Disease Progression
Lung Neoplasms
Cardiovascular Diseases

Keywords

  • Cancer
  • DNA methylation
  • Epigenetics
  • Prenatal smoke exposure
  • Smoking

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Smoking and DNA methylation : Correlation of methylation with smoking behavior and association with diseases and fetus development following prenatal exposure. / Fragou, Domniki; Pakkidi, Eleni; Aschner, Michael; Samanidou, Victoria; Kovatsi, Leda.

In: Food and Chemical Toxicology, Vol. 129, 01.07.2019, p. 312-327.

Research output: Contribution to journalReview article

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AU - Samanidou, Victoria

AU - Kovatsi, Leda

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