Small molecule tyrosine kinase inhibitors and pancreatic cancer—Trials and troubles

Bhaskar Venkata Kameswara Subrahmanya Lakkakula, Batoul Farran, Saikrishna Lakkakula, Sujatha Peela, Nagendra Sastry Yarla, Pallaval Veera Bramhachari, Mohammad Amjad Kamal, Madhu Sudhana Saddala, Ganji Purnachandra Nagaraju

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Pancreatic cancer (PC) is an aggressive carcinoma and the fourth cause of cancer deaths in Western countries. Although surgery is the most effective therapeutic option for PC, the management of unresectable, locally advanced disease is highly challenging. Our improved understanding of pancreatic tumor biology and associated pathways has led to the development of various treatment modalities that can control the metastatic spread of PC. This review intends to present trials of small molecule tyrosine kinase inhibitors (TKIs) in PC management and the troubles encountered due to inevitable acquired resistance to TKIs.

Original languageEnglish (US)
Pages (from-to)149-167
Number of pages19
JournalSeminars in Cancer Biology
Volume56
DOIs
StatePublished - Jun 2019
Externally publishedYes

Keywords

  • Clinical trials
  • Pancreatic carcinoma
  • Resistance
  • Targeted therapies
  • Tyrosine kinase inhibitors

ASJC Scopus subject areas

  • Cancer Research

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