Small-molecule modulators of the NF-κB pathway newly identified by a translocation-based cellular assay

Yuli Xie, Alison Rinderspacher, Yidong Liu, Gangli Gong, Deborah H. Smith, Michael Wyler, Lars Brandén, Shi Xian Deng

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nuclear factor kappa B (NF-κB) is an important transcription factor. Aberrant regulation of the NF-κB pathway is frequently observed in a number of major ailments such as cancer and inflammatory diseases. Hence NF-κB modulators have been intensely pursued for their potential therapeutic applications. Numerous reviews have described recent progress in the development of these agents. More recently, a variety of structurally and functionally novel small molecules, identified through high-throughput screens conducted within the Molecular Libraries Screening Center Network (MLSCN) of the NIH Roadmap for Medical Research, have been added to the current list of NF-??B regulators. This review will discuss the inhibitors and activators newly discovered by Columbia's Molecular Libraries Screening Center (MLSC) using a well-designed and stable cellular assay.

Original languageEnglish (US)
Pages (from-to)1172-1180
Number of pages9
JournalCurrent Topics in Medicinal Chemistry
Volume9
Issue number13
DOIs
StatePublished - 2009
Externally publishedYes

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NF-kappa B
Biomedical Research
Transcription Factors
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Small-molecule modulators of the NF-κB pathway newly identified by a translocation-based cellular assay. / Xie, Yuli; Rinderspacher, Alison; Liu, Yidong; Gong, Gangli; Smith, Deborah H.; Wyler, Michael; Brandén, Lars; Deng, Shi Xian.

In: Current Topics in Medicinal Chemistry, Vol. 9, No. 13, 2009, p. 1172-1180.

Research output: Contribution to journalArticle

Xie, Y, Rinderspacher, A, Liu, Y, Gong, G, Smith, DH, Wyler, M, Brandén, L & Deng, SX 2009, 'Small-molecule modulators of the NF-κB pathway newly identified by a translocation-based cellular assay', Current Topics in Medicinal Chemistry, vol. 9, no. 13, pp. 1172-1180. https://doi.org/10.2174/156802609789753617
Xie, Yuli ; Rinderspacher, Alison ; Liu, Yidong ; Gong, Gangli ; Smith, Deborah H. ; Wyler, Michael ; Brandén, Lars ; Deng, Shi Xian. / Small-molecule modulators of the NF-κB pathway newly identified by a translocation-based cellular assay. In: Current Topics in Medicinal Chemistry. 2009 ; Vol. 9, No. 13. pp. 1172-1180.
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