TY - JOUR
T1 - Small-molecule modulators of the NF-κB pathway newly identified by a translocation-based cellular assay
AU - Xie, Yuli
AU - Rinderspacher, Alison
AU - Liu, Yidong
AU - Gong, Gangli
AU - Smith, Deborah H.
AU - Wyler, Michael
AU - Brandén, Lars
AU - Deng, Shi Xian
PY - 2009
Y1 - 2009
N2 - Nuclear factor kappa B (NF-κB) is an important transcription factor. Aberrant regulation of the NF-κB pathway is frequently observed in a number of major ailments such as cancer and inflammatory diseases. Hence NF-κB modulators have been intensely pursued for their potential therapeutic applications. Numerous reviews have described recent progress in the development of these agents. More recently, a variety of structurally and functionally novel small molecules, identified through high-throughput screens conducted within the Molecular Libraries Screening Center Network (MLSCN) of the NIH Roadmap for Medical Research, have been added to the current list of NF-??B regulators. This review will discuss the inhibitors and activators newly discovered by Columbia's Molecular Libraries Screening Center (MLSC) using a well-designed and stable cellular assay.
AB - Nuclear factor kappa B (NF-κB) is an important transcription factor. Aberrant regulation of the NF-κB pathway is frequently observed in a number of major ailments such as cancer and inflammatory diseases. Hence NF-κB modulators have been intensely pursued for their potential therapeutic applications. Numerous reviews have described recent progress in the development of these agents. More recently, a variety of structurally and functionally novel small molecules, identified through high-throughput screens conducted within the Molecular Libraries Screening Center Network (MLSCN) of the NIH Roadmap for Medical Research, have been added to the current list of NF-??B regulators. This review will discuss the inhibitors and activators newly discovered by Columbia's Molecular Libraries Screening Center (MLSC) using a well-designed and stable cellular assay.
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U2 - 10.2174/156802609789753617
DO - 10.2174/156802609789753617
M3 - Review article
C2 - 19807665
AN - SCOPUS:74249109289
SN - 1568-0266
VL - 9
SP - 1172
EP - 1180
JO - Current topics in medicinal chemistry
JF - Current topics in medicinal chemistry
IS - 13
ER -