Small-molecule modulators of the NF-κB pathway newly identified by a translocation-based cellular assay

Yuli Xie, Alison Rinderspacher, Yidong Liu, Gangli Gong, Deborah H. Smith, Michael Wyler, Lars Brandén, Shi Xian Deng

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Nuclear factor kappa B (NF-κB) is an important transcription factor. Aberrant regulation of the NF-κB pathway is frequently observed in a number of major ailments such as cancer and inflammatory diseases. Hence NF-κB modulators have been intensely pursued for their potential therapeutic applications. Numerous reviews have described recent progress in the development of these agents. More recently, a variety of structurally and functionally novel small molecules, identified through high-throughput screens conducted within the Molecular Libraries Screening Center Network (MLSCN) of the NIH Roadmap for Medical Research, have been added to the current list of NF-??B regulators. This review will discuss the inhibitors and activators newly discovered by Columbia's Molecular Libraries Screening Center (MLSC) using a well-designed and stable cellular assay.

Original languageEnglish (US)
Pages (from-to)1172-1180
Number of pages9
JournalCurrent topics in medicinal chemistry
Volume9
Issue number13
DOIs
StatePublished - Dec 1 2009

ASJC Scopus subject areas

  • Drug Discovery

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    Xie, Y., Rinderspacher, A., Liu, Y., Gong, G., Smith, D. H., Wyler, M., Brandén, L., & Deng, S. X. (2009). Small-molecule modulators of the NF-κB pathway newly identified by a translocation-based cellular assay. Current topics in medicinal chemistry, 9(13), 1172-1180. https://doi.org/10.2174/156802609789753617