Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits

Thomas Blank, Ingrid Nijholt, Min Jeong Kye, Jelena Radulovic, Joachim Spiess

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks is correlated with substantial changes in neuronal signal processing in the hippocampus. Here we show that elevated expression of small-conductance Ca 2+-activated K+ channels (SK channels) of the SK3 type in hippocampi of aged mice contributes to reduced long-term potentiation (LTP) and impaired trace fear conditioning, a hippocampus-dependent learning task.

Original languageEnglish (US)
Pages (from-to)911-912
Number of pages2
JournalNature Neuroscience
Volume6
Issue number9
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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