Sleep, sleep disordered breathing, and nocturnal hypoventilation in children with neuromuscular diseases

Raanan Arens, Hiren Muzumdar

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Sleep disordered breathing (SDB) is now well recognized in children with neuromuscular diseases (NMD) and may lead to significant morbidity and increased mortality. Predisposing factors to SDB in children with NMD include reduced ventilatory responses, reduced activity of respiratory muscles during sleep and poor lung mechanics due to the underlying neuro-muscular disorder. SDB may present long before signs of respiratory failure emerge. When untreated, SDB may contribute to significant cardiovascular morbidities, neuro-cognitive deficits and premature death. One of the problems in detecting SDB in patients with NMD is the lack of correlation between lung function testing and daytime gas exchange. Polysomnography is the preferred method to evaluate for SDB in children with NMD. When the diagnosis of SDB is confirmed, treatment by non-invasive ventilation (NIV) is usually recommended. However, other modalities of mechanical ventilation do exist and may be indicated in combination with or without other supportive measures.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalPaediatric Respiratory Reviews
Volume11
Issue number1
DOIs
StatePublished - Mar 2010

Fingerprint

Hypoventilation
Neuromuscular Diseases
Sleep Apnea Syndromes
Sleep
Morbidity
Noninvasive Ventilation
Lung
Respiratory Muscles
Premature Mortality
Polysomnography
Mechanics
Artificial Respiration
Respiratory Insufficiency
Causality
Gases
Mortality

Keywords

  • hypoventilation
  • neuromuscular diseases (NMD)
  • non invasive ventilation (NIV)
  • obstructive sleep apnoea (OSA)
  • polysomnography
  • sleep disordered breathing (SDB)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Sleep, sleep disordered breathing, and nocturnal hypoventilation in children with neuromuscular diseases. / Arens, Raanan; Muzumdar, Hiren.

In: Paediatric Respiratory Reviews, Vol. 11, No. 1, 03.2010, p. 24-30.

Research output: Contribution to journalArticle

@article{2cdec741da614029b934f3c4ff033ce2,
title = "Sleep, sleep disordered breathing, and nocturnal hypoventilation in children with neuromuscular diseases",
abstract = "Sleep disordered breathing (SDB) is now well recognized in children with neuromuscular diseases (NMD) and may lead to significant morbidity and increased mortality. Predisposing factors to SDB in children with NMD include reduced ventilatory responses, reduced activity of respiratory muscles during sleep and poor lung mechanics due to the underlying neuro-muscular disorder. SDB may present long before signs of respiratory failure emerge. When untreated, SDB may contribute to significant cardiovascular morbidities, neuro-cognitive deficits and premature death. One of the problems in detecting SDB in patients with NMD is the lack of correlation between lung function testing and daytime gas exchange. Polysomnography is the preferred method to evaluate for SDB in children with NMD. When the diagnosis of SDB is confirmed, treatment by non-invasive ventilation (NIV) is usually recommended. However, other modalities of mechanical ventilation do exist and may be indicated in combination with or without other supportive measures.",
keywords = "hypoventilation, neuromuscular diseases (NMD), non invasive ventilation (NIV), obstructive sleep apnoea (OSA), polysomnography, sleep disordered breathing (SDB)",
author = "Raanan Arens and Hiren Muzumdar",
year = "2010",
month = "3",
doi = "10.1016/j.prrv.2009.10.003",
language = "English (US)",
volume = "11",
pages = "24--30",
journal = "Paediatric Respiratory Reviews",
issn = "1526-0550",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Sleep, sleep disordered breathing, and nocturnal hypoventilation in children with neuromuscular diseases

AU - Arens, Raanan

AU - Muzumdar, Hiren

PY - 2010/3

Y1 - 2010/3

N2 - Sleep disordered breathing (SDB) is now well recognized in children with neuromuscular diseases (NMD) and may lead to significant morbidity and increased mortality. Predisposing factors to SDB in children with NMD include reduced ventilatory responses, reduced activity of respiratory muscles during sleep and poor lung mechanics due to the underlying neuro-muscular disorder. SDB may present long before signs of respiratory failure emerge. When untreated, SDB may contribute to significant cardiovascular morbidities, neuro-cognitive deficits and premature death. One of the problems in detecting SDB in patients with NMD is the lack of correlation between lung function testing and daytime gas exchange. Polysomnography is the preferred method to evaluate for SDB in children with NMD. When the diagnosis of SDB is confirmed, treatment by non-invasive ventilation (NIV) is usually recommended. However, other modalities of mechanical ventilation do exist and may be indicated in combination with or without other supportive measures.

AB - Sleep disordered breathing (SDB) is now well recognized in children with neuromuscular diseases (NMD) and may lead to significant morbidity and increased mortality. Predisposing factors to SDB in children with NMD include reduced ventilatory responses, reduced activity of respiratory muscles during sleep and poor lung mechanics due to the underlying neuro-muscular disorder. SDB may present long before signs of respiratory failure emerge. When untreated, SDB may contribute to significant cardiovascular morbidities, neuro-cognitive deficits and premature death. One of the problems in detecting SDB in patients with NMD is the lack of correlation between lung function testing and daytime gas exchange. Polysomnography is the preferred method to evaluate for SDB in children with NMD. When the diagnosis of SDB is confirmed, treatment by non-invasive ventilation (NIV) is usually recommended. However, other modalities of mechanical ventilation do exist and may be indicated in combination with or without other supportive measures.

KW - hypoventilation

KW - neuromuscular diseases (NMD)

KW - non invasive ventilation (NIV)

KW - obstructive sleep apnoea (OSA)

KW - polysomnography

KW - sleep disordered breathing (SDB)

UR - http://www.scopus.com/inward/record.url?scp=75149197895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75149197895&partnerID=8YFLogxK

U2 - 10.1016/j.prrv.2009.10.003

DO - 10.1016/j.prrv.2009.10.003

M3 - Article

VL - 11

SP - 24

EP - 30

JO - Paediatric Respiratory Reviews

JF - Paediatric Respiratory Reviews

SN - 1526-0550

IS - 1

ER -