Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study

Peter D. Ahiawodzi; Richard A. Kerber; Kira C. Taylor; Frank D. Groves; Elizabeth O'Brien; Joachim H. Ix; Jorge R. Kizer; Luc Djoussé; Russell P. Tracy; Anne B. Newman; David S. Siscovick; John Robbins; Kenneth Mukamal

doi:10.1080/1354750X.2016.1276966

Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study

Peter D. Ahiawodzi, Richard A. Kerber, Kira C. Taylor, Frank D. Groves, Elizabeth O'Brien, Joachim H. Ix, Jorge R. Kizer, Luc Djoussé, Russell P. Tracy, Anne B. Newman, David S. Siscovick, John Robbins, Kenneth Mukamal

Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB)–a source of oxidative stress–and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB.

Original language	English (US)
Pages (from-to)	361-366
Number of pages	6
Journal	Biomarkers
Volume	22
Issue number	3-4
DOIs	https://doi.org/10.1080/1354750X.2016.1276966
State	Published - May 19 2017

Keywords

Apnea–Hypopnea Index
Carboxymethyl-lysine
advanced glycation end-product
oxidative stress
sleep-disordered breathing

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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Ahiawodzi, P. D., Kerber, R. A., Taylor, K. C., Groves, F. D., O'Brien, E., Ix, J. H., Kizer, J. R., Djoussé, L., Tracy, R. P., Newman, A. B., Siscovick, D. S., Robbins, J., & Mukamal, K. (2017). Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study. Biomarkers, 22(3-4), 361-366. https://doi.org/10.1080/1354750X.2016.1276966

Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study. / Ahiawodzi, Peter D.; Kerber, Richard A.; Taylor, Kira C.; Groves, Frank D.; O'Brien, Elizabeth; Ix, Joachim H.; Kizer, Jorge R.; Djoussé, Luc; Tracy, Russell P.; Newman, Anne B.; Siscovick, David S.; Robbins, John; Mukamal, Kenneth.

In: Biomarkers, Vol. 22, No. 3-4, 19.05.2017, p. 361-366.

Research output: Contribution to journal › Article › peer-review

Ahiawodzi, PD, Kerber, RA, Taylor, KC, Groves, FD, O'Brien, E, Ix, JH, Kizer, JR, Djoussé, L, Tracy, RP, Newman, AB, Siscovick, DS, Robbins, J & Mukamal, K 2017, 'Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study', Biomarkers, vol. 22, no. 3-4, pp. 361-366. https://doi.org/10.1080/1354750X.2016.1276966

Ahiawodzi, Peter D. ; Kerber, Richard A. ; Taylor, Kira C. ; Groves, Frank D. ; O'Brien, Elizabeth ; Ix, Joachim H. ; Kizer, Jorge R. ; Djoussé, Luc ; Tracy, Russell P. ; Newman, Anne B. ; Siscovick, David S. ; Robbins, John ; Mukamal, Kenneth. / Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study. In: Biomarkers. 2017 ; Vol. 22, No. 3-4. pp. 361-366.

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title = "Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study",

abstract = "Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB)–a source of oxidative stress–and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB.",

keywords = "Apnea–Hypopnea Index, Carboxymethyl-lysine, advanced glycation end-product, oxidative stress, sleep-disordered breathing",

author = "Ahiawodzi, {Peter D.} and Kerber, {Richard A.} and Taylor, {Kira C.} and Groves, {Frank D.} and Elizabeth O'Brien and Ix, {Joachim H.} and Kizer, {Jorge R.} and Luc Djouss{\'e} and Tracy, {Russell P.} and Newman, {Anne B.} and Siscovick, {David S.} and John Robbins and Kenneth Mukamal",

note = "Funding Information: This research was supported by R01HL094555, as well as by Contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083 and N01HC85086, and Grant U01HL080295 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided by R01AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at http://www.chs-nhlbi.org/PI.",

year = "2017",

month = may,

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doi = "10.1080/1354750X.2016.1276966",

language = "English (US)",

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T1 - Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study

AU - Ahiawodzi, Peter D.

AU - Kerber, Richard A.

AU - Taylor, Kira C.

AU - Groves, Frank D.

AU - O'Brien, Elizabeth

AU - Ix, Joachim H.

AU - Kizer, Jorge R.

AU - Djoussé, Luc

AU - Tracy, Russell P.

AU - Newman, Anne B.

AU - Siscovick, David S.

AU - Robbins, John

AU - Mukamal, Kenneth

N1 - Funding Information: This research was supported by R01HL094555, as well as by Contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083 and N01HC85086, and Grant U01HL080295 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided by R01AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at http://www.chs-nhlbi.org/PI.

PY - 2017/5/19

Y1 - 2017/5/19

N2 - Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB)–a source of oxidative stress–and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB.

AB - Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB)–a source of oxidative stress–and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB.

KW - Apnea–Hypopnea Index

KW - Carboxymethyl-lysine

KW - advanced glycation end-product

KW - oxidative stress

KW - sleep-disordered breathing

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