Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study

Peter D. Ahiawodzi; Richard A. Kerber; Kira C. Taylor; Frank D. Groves; Elizabeth O'Brien; Joachim H. Ix; Jorge R. Kizer; Luc Djoussé; Russell P. Tracy; Anne B. Newman; David S. Siscovick; John Robbins; Kenneth Mukamal

doi:10.1080/1354750X.2016.1276966

Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study

Peter D. Ahiawodzi, Richard A. Kerber, Kira C. Taylor, Frank D. Groves, Elizabeth O'Brien, Joachim H. Ix, Jorge R. Kizer, Luc Djoussé, Russell P. Tracy, Anne B. Newman, David S. Siscovick, John Robbins, Kenneth Mukamal

Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB)–a source of oxidative stress–and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB.

Original language	English (US)
Pages (from-to)	361-366
Number of pages	6
Journal	Biomarkers
Volume	22
Issue number	3-4
DOIs	https://doi.org/10.1080/1354750X.2016.1276966
State	Published - May 19 2017

Keywords

Apnea–Hypopnea Index
Carboxymethyl-lysine
advanced glycation end-product
oxidative stress
sleep-disordered breathing

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/1354750X.2016.1276966

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Ahiawodzi, P. D., Kerber, R. A., Taylor, K. C., Groves, F. D., O'Brien, E., Ix, J. H., Kizer, J. R., Djoussé, L., Tracy, R. P., Newman, A. B., Siscovick, D. S., Robbins, J., & Mukamal, K. (2017). Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study. Biomarkers, 22(3-4), 361-366. https://doi.org/10.1080/1354750X.2016.1276966

Ahiawodzi, PD, Kerber, RA, Taylor, KC, Groves, FD, O'Brien, E, Ix, JH, Kizer, JR, Djoussé, L, Tracy, RP, Newman, AB, Siscovick, DS, Robbins, J & Mukamal, K 2017, 'Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study', Biomarkers, vol. 22, no. 3-4, pp. 361-366. https://doi.org/10.1080/1354750X.2016.1276966

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title = "Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study",

abstract = "Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB)–a source of oxidative stress–and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB.",

keywords = "Apnea–Hypopnea Index, Carboxymethyl-lysine, advanced glycation end-product, oxidative stress, sleep-disordered breathing",

author = "Ahiawodzi, {Peter D.} and Kerber, {Richard A.} and Taylor, {Kira C.} and Groves, {Frank D.} and Elizabeth O'Brien and Ix, {Joachim H.} and Kizer, {Jorge R.} and Luc Djouss{\'e} and Tracy, {Russell P.} and Newman, {Anne B.} and Siscovick, {David S.} and John Robbins and Kenneth Mukamal",

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year = "2017",

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doi = "10.1080/1354750X.2016.1276966",

language = "English (US)",

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AU - Ahiawodzi, Peter D.

AU - Kerber, Richard A.

AU - Taylor, Kira C.

AU - Groves, Frank D.

AU - O'Brien, Elizabeth

AU - Ix, Joachim H.

AU - Kizer, Jorge R.

AU - Djoussé, Luc

AU - Tracy, Russell P.

AU - Newman, Anne B.

AU - Siscovick, David S.

AU - Robbins, John

AU - Mukamal, Kenneth

PY - 2017/5/19

Y1 - 2017/5/19

N2 - Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB)–a source of oxidative stress–and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB.

AB - Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB)–a source of oxidative stress–and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB.

KW - Apnea–Hypopnea Index

KW - Carboxymethyl-lysine

KW - advanced glycation end-product

KW - oxidative stress

KW - sleep-disordered breathing

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Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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