Sleep-Disordered Breathing Is Associated With Higher Carboxymethyllysine Level In Elderly Women But Not Elderly Men In The Cardiovascular Health Study

Peter D. Ahiawodzi; Richard A. Kerber; Kira C. Taylor; Frank D. Groves; Elizabeth O'Brien; Joachim H. Ix; Jorge Kizer; Luc Djoussé; Russell P. Tracy; Anne B. Newman; David S. Siscovick; John Robbins; Kenneth Mukamal

doi:10.1080/1354750X.2016.1276966

Sleep-Disordered Breathing Is Associated With Higher Carboxymethyllysine Level In Elderly Women But Not Elderly Men In The Cardiovascular Health Study

Peter D. Ahiawodzi, Richard A. Kerber, Kira C. Taylor, Frank D. Groves, Elizabeth O'Brien, Joachim H. Ix, Jorge Kizer, Luc Djoussé, Russell P. Tracy, Anne B. Newman, David S. Siscovick, John Robbins, Kenneth Mukamal

Medicine

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB) – a source of oxidative stress – and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Biomarkers
DOIs	https://doi.org/10.1080/1354750X.2016.1276966
State	Accepted/In press - Jan 20 2017

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Keywords

advanced glycation end-product
Apnea–Hypopnea Index
Carboxymethyl-lysine
oxidative stress
sleep-disordered breathing

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

Cite this

Ahiawodzi, P. D., Kerber, R. A., Taylor, K. C., Groves, F. D., O'Brien, E., Ix, J. H., Kizer, J., Djoussé, L., Tracy, R. P., Newman, A. B., Siscovick, D. S., Robbins, J., & Mukamal, K. (Accepted/In press). Sleep-Disordered Breathing Is Associated With Higher Carboxymethyllysine Level In Elderly Women But Not Elderly Men In The Cardiovascular Health Study. Biomarkers, 1-6. https://doi.org/10.1080/1354750X.2016.1276966

Sleep-Disordered Breathing Is Associated With Higher Carboxymethyllysine Level In Elderly Women But Not Elderly Men In The Cardiovascular Health Study. / Ahiawodzi, Peter D.; Kerber, Richard A.; Taylor, Kira C.; Groves, Frank D.; O'Brien, Elizabeth; Ix, Joachim H.; Kizer, Jorge; Djoussé, Luc; Tracy, Russell P.; Newman, Anne B.; Siscovick, David S.; Robbins, John; Mukamal, Kenneth.

In: Biomarkers, 20.01.2017, p. 1-6.

Research output: Contribution to journal › Article

Ahiawodzi, PD, Kerber, RA, Taylor, KC, Groves, FD, O'Brien, E, Ix, JH, Kizer, J, Djoussé, L, Tracy, RP, Newman, AB, Siscovick, DS, Robbins, J & Mukamal, K 2017, 'Sleep-Disordered Breathing Is Associated With Higher Carboxymethyllysine Level In Elderly Women But Not Elderly Men In The Cardiovascular Health Study', Biomarkers, pp. 1-6. https://doi.org/10.1080/1354750X.2016.1276966

Ahiawodzi, Peter D. ; Kerber, Richard A. ; Taylor, Kira C. ; Groves, Frank D. ; O'Brien, Elizabeth ; Ix, Joachim H. ; Kizer, Jorge ; Djoussé, Luc ; Tracy, Russell P. ; Newman, Anne B. ; Siscovick, David S. ; Robbins, John ; Mukamal, Kenneth. / Sleep-Disordered Breathing Is Associated With Higher Carboxymethyllysine Level In Elderly Women But Not Elderly Men In The Cardiovascular Health Study. In: Biomarkers. 2017 ; pp. 1-6.

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abstract = "Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB) – a source of oxidative stress – and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB",

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10.1080/1354750X.2016.1276966