Sleep-Disordered Breathing Is Associated With Higher Carboxymethyllysine Level In Elderly Women But Not Elderly Men In The Cardiovascular Health Study

Peter D. Ahiawodzi, Richard A. Kerber, Kira C. Taylor, Frank D. Groves, Elizabeth O'Brien, Joachim H. Ix, Jorge Kizer, Luc Djoussé, Russell P. Tracy, Anne B. Newman, David S. Siscovick, John Robbins, Kenneth Mukamal

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB) – a source of oxidative stress – and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalBiomarkers
DOIs
StateAccepted/In press - Jan 20 2017

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Keywords

  • advanced glycation end-product
  • Apnea–Hypopnea Index
  • Carboxymethyl-lysine
  • oxidative stress
  • sleep-disordered breathing

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Ahiawodzi, P. D., Kerber, R. A., Taylor, K. C., Groves, F. D., O'Brien, E., Ix, J. H., Kizer, J., Djoussé, L., Tracy, R. P., Newman, A. B., Siscovick, D. S., Robbins, J., & Mukamal, K. (Accepted/In press). Sleep-Disordered Breathing Is Associated With Higher Carboxymethyllysine Level In Elderly Women But Not Elderly Men In The Cardiovascular Health Study. Biomarkers, 1-6. https://doi.org/10.1080/1354750X.2016.1276966