Sleep and cardiometabolic function in obese adolescent girls with polycystic ovary syndrome

Kiran Nandalike, Chhavi Agarwal, Temima Strauss, Susan M. Coupey, Carmen R. Isasi, Sanghun Sin, Raanan Arens

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective: To compare the polysomnography findings and cardiometabolic function among adolescent girls with polycystic ovary syndrome (PCOS) and matched female and male controls. Method: Retrospective chart review of electronic medical records of 28 girls with PCOS (age: 16.8 ± 1.9. years, body mass index (BMI) Z-score 2.4 ± 0.4), 28 control females (age: 17.1 ± 1.8, BMI Z-score 2.4 ± 0.3) and 28 control males (age: 16.6 ± 1.6, BMI Z-score 2.5 ± 0.5) in a tertiary care centre. Results: The prevalence of obstructive sleep apnoea (OSA) was higher in girls with PCOS compared to control females (16/28 (57%) vs. 4/28(14.3%), p<0.01); however, it was comparable to that of the control males (16/28(57%) vs. 21/28(75%), p=0.4). Girls with PCOS had a significantly higher prevalence of insulin resistance compared to control females and control males (20/28 (71.4%) vs. 9/22 (41.0%) (p=0.04) vs. 8/23 (34.8%) (p=0.01). Among girls with PCOS, those with OSA had significantly higher proportions of metabolic syndrome (MetS) (9/16 (56.3%) vs. 1/12 (8.3%) p=0.03), higher insulin resistance (14/16 (87.5%) vs. 6/12 (50%), p=0.04), elevated daytime systolic blood pressure (128.4 ± 12.8 vs. 115.6 ± 11.4, p<0.01), lower high-density lipoprotein (HDL) (38.6 ± 8.7 vs. 49 ± 10.9, p=0.01) and elevated triglycerides (TG) (149.7 ± 87.7 vs. 93.3 ± 25.8, p=0.03) compared to those without OSA. Conclusions: We report a higher prevalence of OSA and metabolic dysfunction in a selected group of obese girls with PCOS referred with sleep-related complaints compared to BMI-matched control girls without PCOS. We also report higher prevalence of cardiometabolic dysfunction in girls with PCOS and OSA compared to girls with PCOS without OSA.

Original languageEnglish (US)
Pages (from-to)1307-1312
Number of pages6
JournalSleep Medicine
Volume13
Issue number10
DOIs
StatePublished - Dec 2012

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Polycystic Ovary Syndrome
Sleep
Obstructive Sleep Apnea
Body Mass Index
Insulin Resistance
Blood Pressure
Polysomnography
Electronic Health Records
HDL Lipoproteins
Tertiary Care Centers
Triglycerides

Keywords

  • AHI: apnoea hypopnoea index
  • HDL: high-density lipoprotein
  • HOMA-IR: homeostatic model assessment a measure of Insulin resistance
  • MetS: metabolic syndrome
  • OSA: obstructive sleep apnoea
  • PCOS: polycystic ovary syndrome
  • TG: triglyceride

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sleep and cardiometabolic function in obese adolescent girls with polycystic ovary syndrome. / Nandalike, Kiran; Agarwal, Chhavi; Strauss, Temima; Coupey, Susan M.; Isasi, Carmen R.; Sin, Sanghun; Arens, Raanan.

In: Sleep Medicine, Vol. 13, No. 10, 12.2012, p. 1307-1312.

Research output: Contribution to journalArticle

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abstract = "Objective: To compare the polysomnography findings and cardiometabolic function among adolescent girls with polycystic ovary syndrome (PCOS) and matched female and male controls. Method: Retrospective chart review of electronic medical records of 28 girls with PCOS (age: 16.8 ± 1.9. years, body mass index (BMI) Z-score 2.4 ± 0.4), 28 control females (age: 17.1 ± 1.8, BMI Z-score 2.4 ± 0.3) and 28 control males (age: 16.6 ± 1.6, BMI Z-score 2.5 ± 0.5) in a tertiary care centre. Results: The prevalence of obstructive sleep apnoea (OSA) was higher in girls with PCOS compared to control females (16/28 (57{\%}) vs. 4/28(14.3{\%}), p<0.01); however, it was comparable to that of the control males (16/28(57{\%}) vs. 21/28(75{\%}), p=0.4). Girls with PCOS had a significantly higher prevalence of insulin resistance compared to control females and control males (20/28 (71.4{\%}) vs. 9/22 (41.0{\%}) (p=0.04) vs. 8/23 (34.8{\%}) (p=0.01). Among girls with PCOS, those with OSA had significantly higher proportions of metabolic syndrome (MetS) (9/16 (56.3{\%}) vs. 1/12 (8.3{\%}) p=0.03), higher insulin resistance (14/16 (87.5{\%}) vs. 6/12 (50{\%}), p=0.04), elevated daytime systolic blood pressure (128.4 ± 12.8 vs. 115.6 ± 11.4, p<0.01), lower high-density lipoprotein (HDL) (38.6 ± 8.7 vs. 49 ± 10.9, p=0.01) and elevated triglycerides (TG) (149.7 ± 87.7 vs. 93.3 ± 25.8, p=0.03) compared to those without OSA. Conclusions: We report a higher prevalence of OSA and metabolic dysfunction in a selected group of obese girls with PCOS referred with sleep-related complaints compared to BMI-matched control girls without PCOS. We also report higher prevalence of cardiometabolic dysfunction in girls with PCOS and OSA compared to girls with PCOS without OSA.",
keywords = "AHI: apnoea hypopnoea index, HDL: high-density lipoprotein, HOMA-IR: homeostatic model assessment a measure of Insulin resistance, MetS: metabolic syndrome, OSA: obstructive sleep apnoea, PCOS: polycystic ovary syndrome, TG: triglyceride",
author = "Kiran Nandalike and Chhavi Agarwal and Temima Strauss and Coupey, {Susan M.} and Isasi, {Carmen R.} and Sanghun Sin and Raanan Arens",
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T1 - Sleep and cardiometabolic function in obese adolescent girls with polycystic ovary syndrome

AU - Nandalike, Kiran

AU - Agarwal, Chhavi

AU - Strauss, Temima

AU - Coupey, Susan M.

AU - Isasi, Carmen R.

AU - Sin, Sanghun

AU - Arens, Raanan

PY - 2012/12

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N2 - Objective: To compare the polysomnography findings and cardiometabolic function among adolescent girls with polycystic ovary syndrome (PCOS) and matched female and male controls. Method: Retrospective chart review of electronic medical records of 28 girls with PCOS (age: 16.8 ± 1.9. years, body mass index (BMI) Z-score 2.4 ± 0.4), 28 control females (age: 17.1 ± 1.8, BMI Z-score 2.4 ± 0.3) and 28 control males (age: 16.6 ± 1.6, BMI Z-score 2.5 ± 0.5) in a tertiary care centre. Results: The prevalence of obstructive sleep apnoea (OSA) was higher in girls with PCOS compared to control females (16/28 (57%) vs. 4/28(14.3%), p<0.01); however, it was comparable to that of the control males (16/28(57%) vs. 21/28(75%), p=0.4). Girls with PCOS had a significantly higher prevalence of insulin resistance compared to control females and control males (20/28 (71.4%) vs. 9/22 (41.0%) (p=0.04) vs. 8/23 (34.8%) (p=0.01). Among girls with PCOS, those with OSA had significantly higher proportions of metabolic syndrome (MetS) (9/16 (56.3%) vs. 1/12 (8.3%) p=0.03), higher insulin resistance (14/16 (87.5%) vs. 6/12 (50%), p=0.04), elevated daytime systolic blood pressure (128.4 ± 12.8 vs. 115.6 ± 11.4, p<0.01), lower high-density lipoprotein (HDL) (38.6 ± 8.7 vs. 49 ± 10.9, p=0.01) and elevated triglycerides (TG) (149.7 ± 87.7 vs. 93.3 ± 25.8, p=0.03) compared to those without OSA. Conclusions: We report a higher prevalence of OSA and metabolic dysfunction in a selected group of obese girls with PCOS referred with sleep-related complaints compared to BMI-matched control girls without PCOS. We also report higher prevalence of cardiometabolic dysfunction in girls with PCOS and OSA compared to girls with PCOS without OSA.

AB - Objective: To compare the polysomnography findings and cardiometabolic function among adolescent girls with polycystic ovary syndrome (PCOS) and matched female and male controls. Method: Retrospective chart review of electronic medical records of 28 girls with PCOS (age: 16.8 ± 1.9. years, body mass index (BMI) Z-score 2.4 ± 0.4), 28 control females (age: 17.1 ± 1.8, BMI Z-score 2.4 ± 0.3) and 28 control males (age: 16.6 ± 1.6, BMI Z-score 2.5 ± 0.5) in a tertiary care centre. Results: The prevalence of obstructive sleep apnoea (OSA) was higher in girls with PCOS compared to control females (16/28 (57%) vs. 4/28(14.3%), p<0.01); however, it was comparable to that of the control males (16/28(57%) vs. 21/28(75%), p=0.4). Girls with PCOS had a significantly higher prevalence of insulin resistance compared to control females and control males (20/28 (71.4%) vs. 9/22 (41.0%) (p=0.04) vs. 8/23 (34.8%) (p=0.01). Among girls with PCOS, those with OSA had significantly higher proportions of metabolic syndrome (MetS) (9/16 (56.3%) vs. 1/12 (8.3%) p=0.03), higher insulin resistance (14/16 (87.5%) vs. 6/12 (50%), p=0.04), elevated daytime systolic blood pressure (128.4 ± 12.8 vs. 115.6 ± 11.4, p<0.01), lower high-density lipoprotein (HDL) (38.6 ± 8.7 vs. 49 ± 10.9, p=0.01) and elevated triglycerides (TG) (149.7 ± 87.7 vs. 93.3 ± 25.8, p=0.03) compared to those without OSA. Conclusions: We report a higher prevalence of OSA and metabolic dysfunction in a selected group of obese girls with PCOS referred with sleep-related complaints compared to BMI-matched control girls without PCOS. We also report higher prevalence of cardiometabolic dysfunction in girls with PCOS and OSA compared to girls with PCOS without OSA.

KW - AHI: apnoea hypopnoea index

KW - HDL: high-density lipoprotein

KW - HOMA-IR: homeostatic model assessment a measure of Insulin resistance

KW - MetS: metabolic syndrome

KW - OSA: obstructive sleep apnoea

KW - PCOS: polycystic ovary syndrome

KW - TG: triglyceride

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U2 - 10.1016/j.sleep.2012.07.002

DO - 10.1016/j.sleep.2012.07.002

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VL - 13

SP - 1307

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JO - Sleep Medicine

JF - Sleep Medicine

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