Skin wrinkles and rigidity in early postmenopausal women vary by race/ethnicity: Baseline characteristics of the skin ancillary study of the KEEPS trial

Erin Wolff, Lubna Pal, Tugba Altun, Rajeevi Madankumar, Ruth Freeman, Hussein Amin, Mitch Harman, Nanette Santoro, Hugh S. Taylor

Research output: Contribution to journalArticle

17 Scopus citations


Objective: To characterize skin wrinkles and rigidity in recently menopausal women. Design: Baseline assessment of participants before randomization to study drug. Setting: Multicenter trial, university medical centers. Patient(s): Recently menopausal participants enrolled in the Kronos Early Estrogen Prevention Study (KEEPS). Intervention(s): Skin wrinkles were assessed at 11 locations on the face and neck using the Lemperle wrinkle scale. Skin rigidity was assessed at the forehead and cheek using a durometer. Main Outcome Measure(s): Skin wrinkles and rigidity were compared among race/ethnic groups. Skin wrinkles and rigidity were correlated with age, time since menopause, weight, and body mass index (BMI). Result(s): In early menopausal women, wrinkles, but not skin rigidity, vary significantly among races, where black women have the lowest wrinkle scores. In white women, chronological age was significantly correlated with worsening skin wrinkles, but not with rigidity. Skin rigidity correlated with increasing length of time since menopause, however, only in the white subgroup. In the combined study group, increasing weight was associated with less skin wrinkling. Conclusion(s): Skin characteristics of recently menopausal women are not well studied. Ethnic differences in skin characteristics are widely accepted, but poorly described. In recently menopausal women not using hormone therapy (HT), significant racial differences in skin wrinkling and rigidity exist. Continued study of the KEEPS population will provide evidence of the effects of HT on the skin aging process in early menopausal women.

Original languageEnglish (US)
Pages (from-to)658-662.e3
JournalFertility and Sterility
Issue number2
Publication statusPublished - Feb 2011



  • Skin
  • durometer
  • estrogen
  • ethnicity
  • hormone therapy
  • menopause
  • race
  • rigidity
  • wrinkles

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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