Six-month gain in weight, height, and CD4 predict subsequent antiretroviral treatment responses in HIV-infected South African children

Marcel Yotebieng, Annelies Van Rie, Harry Moultrie, Tammy Meyers

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

OBJECTIVES: Construct percentile curves for 6-month gain in weight, height, CD4 cell count, and CD4 percentage (CD4%) in children initiating ART, and to assess the association between lower percentiles and subsequent ART responses. DESIGN: Cohort of 1394 HIV-infected children initiating ART between April 2004 and March 2008, Johannesburg, South Africa METHODS: The generalized additive model for location, scale, and shape was used to construct percentile curves for 6-month gain in weight, height, CD4 cell count, and CD4%. Cox proportional models were used to assess the association between lower percentiles of each distribution and death, virological suppression, and treatment failure between 6 to 36 months post-ART initiation. RESULTS: Lower percentiles for gain in weight, CD4, and CD4% count after 6 months of ART, but not height, were associated with poor subsequent treatment outcomes independent of baseline characteristics, with increasing strength of association as percentiles decreased. Age-specific 6-month post-ART weight gain in our cohort was substantially higher compared with 6-month weight gain in non-HIV-infected American children of the Fels Institute cohort and the attained weight-for-age at 6 months post-ART plotted on WHO weight-for-age growth charts were not associated with subsequent treatment outcomes. CONCLUSION: Gain in CD4% in the first 6 months of ART was the best predictor of poor subsequent ART outcomes. In areas with limited access to CD4%, weight gain post-ART using our newly developed reference distributions for HIV-infected children on ART is a good alternative to CD4%, and clearly superior to the commonly used 'Road-to-Health' weight-for-age charts.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalAIDS
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Weight Gain
HIV
CD4 Lymphocyte Count
Weights and Measures
Therapeutics
Growth Charts
South Africa
Treatment Failure
Proportional Hazards Models
Health

Keywords

  • ART monitoring
  • CD4
  • Children
  • South Africa
  • Viral load
  • Weight

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Six-month gain in weight, height, and CD4 predict subsequent antiretroviral treatment responses in HIV-infected South African children. / Yotebieng, Marcel; Van Rie, Annelies; Moultrie, Harry; Meyers, Tammy.

In: AIDS, Vol. 24, No. 1, 01.01.2010, p. 139-146.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVES: Construct percentile curves for 6-month gain in weight, height, CD4 cell count, and CD4 percentage (CD4{\%}) in children initiating ART, and to assess the association between lower percentiles and subsequent ART responses. DESIGN: Cohort of 1394 HIV-infected children initiating ART between April 2004 and March 2008, Johannesburg, South Africa METHODS: The generalized additive model for location, scale, and shape was used to construct percentile curves for 6-month gain in weight, height, CD4 cell count, and CD4{\%}. Cox proportional models were used to assess the association between lower percentiles of each distribution and death, virological suppression, and treatment failure between 6 to 36 months post-ART initiation. RESULTS: Lower percentiles for gain in weight, CD4, and CD4{\%} count after 6 months of ART, but not height, were associated with poor subsequent treatment outcomes independent of baseline characteristics, with increasing strength of association as percentiles decreased. Age-specific 6-month post-ART weight gain in our cohort was substantially higher compared with 6-month weight gain in non-HIV-infected American children of the Fels Institute cohort and the attained weight-for-age at 6 months post-ART plotted on WHO weight-for-age growth charts were not associated with subsequent treatment outcomes. CONCLUSION: Gain in CD4{\%} in the first 6 months of ART was the best predictor of poor subsequent ART outcomes. In areas with limited access to CD4{\%}, weight gain post-ART using our newly developed reference distributions for HIV-infected children on ART is a good alternative to CD4{\%}, and clearly superior to the commonly used 'Road-to-Health' weight-for-age charts.",
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