SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Xiao Tian; Denis Firsanov; Zhihui Zhang; Yang Cheng; Lingfeng Luo; Gregory Tombline; Ruiyue Tan; Matthew Simon; Steven Henderson; Janine Steffan; Audrey Goldfarb; Jonathan Tam; Kitty Zheng; Adam Cornwell; Adam Johnson; Jiang Nan Yang; Zhiyong Mao; Bruno Manta; Weiwei Dang; Zhengdong Zhang; Jan Vijg; Aaron Wolfe; Kelsey Moody; Brian K. Kennedy; Dirk Bohmann; Vadim N. Gladyshev; Andrei Seluanov; Vera Gorbunova

doi:10.1016/j.cell.2019.03.043

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Xiao Tian, Denis Firsanov, Zhihui Zhang, Yang Cheng, Lingfeng Luo, Gregory Tombline, Ruiyue Tan, Matthew Simon, Steven Henderson, Janine Steffan, Audrey Goldfarb, Jonathan Tam, Kitty Zheng, Adam Cornwell, Adam Johnson, Jiang Nan Yang, Zhiyong Mao, Bruno Manta, Weiwei Dang, Zhengdong ZhangJan Vijg, Aaron Wolfe, Kelsey Moody, Brian K. Kennedy, Dirk Bohmann, Vadim N. Gladyshev, Andrei Seluanov, Vera Gorbunova

Genetics

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A comparative analysis of 18 rodent species identifies a role for SIRT6-dependent DNA double strand break repair as a major factor in organismal lifespan

Original language	English (US)
Pages (from-to)	622-638.e22
Journal	Cell
Volume	177
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2019.03.043
State	Published - Apr 18 2019

Keywords

DNA DSB repair
DNA repair
NER
SIRT6
aging
longevity

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2019.03.043

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Tian, X., Firsanov, D., Zhang, Z., Cheng, Y., Luo, L., Tombline, G., Tan, R., Simon, M., Henderson, S., Steffan, J., Goldfarb, A., Tam, J., Zheng, K., Cornwell, A., Johnson, A., Yang, J. N., Mao, Z., Manta, B., Dang, W., ... Gorbunova, V. (2019). SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell, 177(3), 622-638.e22. https://doi.org/10.1016/j.cell.2019.03.043

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. / Tian, Xiao; Firsanov, Denis; Zhang, Zhihui; Cheng, Yang; Luo, Lingfeng; Tombline, Gregory; Tan, Ruiyue; Simon, Matthew; Henderson, Steven; Steffan, Janine; Goldfarb, Audrey; Tam, Jonathan; Zheng, Kitty; Cornwell, Adam; Johnson, Adam; Yang, Jiang Nan; Mao, Zhiyong; Manta, Bruno; Dang, Weiwei; Zhang, Zhengdong ; Vijg, Jan; Wolfe, Aaron; Moody, Kelsey; Kennedy, Brian K.; Bohmann, Dirk; Gladyshev, Vadim N.; Seluanov, Andrei; Gorbunova, Vera.

In: Cell, Vol. 177, No. 3, 18.04.2019, p. 622-638.e22.

Research output: Contribution to journal › Article › peer-review

Tian, X, Firsanov, D, Zhang, Z, Cheng, Y, Luo, L, Tombline, G, Tan, R, Simon, M, Henderson, S, Steffan, J, Goldfarb, A, Tam, J, Zheng, K, Cornwell, A, Johnson, A, Yang, JN, Mao, Z, Manta, B, Dang, W, Zhang, Z , Vijg, J, Wolfe, A, Moody, K, Kennedy, BK, Bohmann, D, Gladyshev, VN, Seluanov, A & Gorbunova, V 2019, 'SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species', Cell, vol. 177, no. 3, pp. 622-638.e22. https://doi.org/10.1016/j.cell.2019.03.043

Tian, Xiao ; Firsanov, Denis ; Zhang, Zhihui ; Cheng, Yang ; Luo, Lingfeng ; Tombline, Gregory ; Tan, Ruiyue ; Simon, Matthew ; Henderson, Steven ; Steffan, Janine ; Goldfarb, Audrey ; Tam, Jonathan ; Zheng, Kitty ; Cornwell, Adam ; Johnson, Adam ; Yang, Jiang Nan ; Mao, Zhiyong ; Manta, Bruno ; Dang, Weiwei ; Zhang, Zhengdong ; Vijg, Jan ; Wolfe, Aaron ; Moody, Kelsey ; Kennedy, Brian K. ; Bohmann, Dirk ; Gladyshev, Vadim N. ; Seluanov, Andrei ; Gorbunova, Vera. / SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. In: Cell. 2019 ; Vol. 177, No. 3. pp. 622-638.e22.

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title = "SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species",

abstract = "A comparative analysis of 18 rodent species identifies a role for SIRT6-dependent DNA double strand break repair as a major factor in organismal lifespan",

keywords = "DNA DSB repair, DNA repair, NER, SIRT6, aging, longevity",

author = "Xiao Tian and Denis Firsanov and Zhihui Zhang and Yang Cheng and Lingfeng Luo and Gregory Tombline and Ruiyue Tan and Matthew Simon and Steven Henderson and Janine Steffan and Audrey Goldfarb and Jonathan Tam and Kitty Zheng and Adam Cornwell and Adam Johnson and Yang, {Jiang Nan} and Zhiyong Mao and Bruno Manta and Weiwei Dang and Zhengdong Zhang and Jan Vijg and Aaron Wolfe and Kelsey Moody and Kennedy, {Brian K.} and Dirk Bohmann and Gladyshev, {Vadim N.} and Andrei Seluanov and Vera Gorbunova",

note = "Funding Information: We thank Dr. Daven Presgraves for suggestions on statistical analysis and Nicholas Macoretta for critically reading the manuscript. This work was supported by the US National Institutes of Health grants to V.G., A.S., V.N.G., Z.Z., and J.V.; and Life Extension Foundation to V.G. and A.S. ",

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AU - Tian, Xiao

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AU - Luo, Lingfeng

AU - Tombline, Gregory

AU - Tan, Ruiyue

AU - Simon, Matthew

AU - Henderson, Steven

AU - Steffan, Janine

AU - Goldfarb, Audrey

AU - Tam, Jonathan

AU - Zheng, Kitty

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AU - Vijg, Jan

AU - Wolfe, Aaron

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AU - Kennedy, Brian K.

AU - Bohmann, Dirk

AU - Gladyshev, Vadim N.

AU - Seluanov, Andrei

AU - Gorbunova, Vera

N1 - Funding Information: We thank Dr. Daven Presgraves for suggestions on statistical analysis and Nicholas Macoretta for critically reading the manuscript. This work was supported by the US National Institutes of Health grants to V.G., A.S., V.N.G., Z.Z., and J.V.; and Life Extension Foundation to V.G. and A.S.

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