SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Xiao Tian; Denis Firsanov; Zhihui Zhang; Yang Cheng; Lingfeng Luo; Gregory Tombline; Ruiyue Tan; Matthew Simon; Steven Henderson; Janine Steffan; Audrey Goldfarb; Jonathan Tam; Kitty Zheng; Adam Cornwell; Adam Johnson; Jiang Nan Yang; Zhiyong Mao; Bruno Manta; Weiwei Dang; Zhengdong Zhang; Jan Vijg; Aaron Wolfe; Kelsey Moody; Brian K. Kennedy; Dirk Bohmann; Vadim N. Gladyshev; Andrei Seluanov; Vera Gorbunova

doi:10.1016/j.cell.2019.03.043

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Xiao Tian, Denis Firsanov, Zhihui Zhang, Yang Cheng, Lingfeng Luo, Gregory Tombline, Ruiyue Tan, Matthew Simon, Steven Henderson, Janine Steffan, Audrey Goldfarb, Jonathan Tam, Kitty Zheng, Adam Cornwell, Adam Johnson, Jiang Nan Yang, Zhiyong Mao, Bruno Manta, Weiwei Dang, Zhengdong ZhangJan Vijg, Aaron Wolfe, Kelsey Moody, Brian K. Kennedy, Dirk Bohmann, Vadim N. Gladyshev, Andrei Seluanov, Vera Gorbunova

Genetics

Research output: Contribution to journal › Article

19 Scopus citations

Abstract

A comparative analysis of 18 rodent species identifies a role for SIRT6-dependent DNA double strand break repair as a major factor in organismal lifespan

Original language	English (US)
Pages (from-to)	622-638.e22
Journal	Cell
Volume	177
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2019.03.043
State	Published - Apr 18 2019

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Keywords

DNA DSB repair
DNA repair
NER
SIRT6
aging
longevity

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tian, X., Firsanov, D., Zhang, Z., Cheng, Y., Luo, L., Tombline, G., Tan, R., Simon, M., Henderson, S., Steffan, J., Goldfarb, A., Tam, J., Zheng, K., Cornwell, A., Johnson, A., Yang, J. N., Mao, Z., Manta, B., Dang, W., ... Gorbunova, V. (2019). SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell, 177(3), 622-638.e22. https://doi.org/10.1016/j.cell.2019.03.043

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. / Tian, Xiao; Firsanov, Denis; Zhang, Zhihui; Cheng, Yang; Luo, Lingfeng; Tombline, Gregory; Tan, Ruiyue; Simon, Matthew; Henderson, Steven; Steffan, Janine; Goldfarb, Audrey; Tam, Jonathan; Zheng, Kitty; Cornwell, Adam; Johnson, Adam; Yang, Jiang Nan; Mao, Zhiyong; Manta, Bruno; Dang, Weiwei; Zhang, Zhengdong ; Vijg, Jan; Wolfe, Aaron; Moody, Kelsey; Kennedy, Brian K.; Bohmann, Dirk; Gladyshev, Vadim N.; Seluanov, Andrei; Gorbunova, Vera.

In: Cell, Vol. 177, No. 3, 18.04.2019, p. 622-638.e22.

Research output: Contribution to journal › Article

Tian, X, Firsanov, D, Zhang, Z, Cheng, Y, Luo, L, Tombline, G, Tan, R, Simon, M, Henderson, S, Steffan, J, Goldfarb, A, Tam, J, Zheng, K, Cornwell, A, Johnson, A, Yang, JN, Mao, Z, Manta, B, Dang, W, Zhang, Z , Vijg, J, Wolfe, A, Moody, K, Kennedy, BK, Bohmann, D, Gladyshev, VN, Seluanov, A & Gorbunova, V 2019, 'SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species', Cell, vol. 177, no. 3, pp. 622-638.e22. https://doi.org/10.1016/j.cell.2019.03.043

Tian, Xiao ; Firsanov, Denis ; Zhang, Zhihui ; Cheng, Yang ; Luo, Lingfeng ; Tombline, Gregory ; Tan, Ruiyue ; Simon, Matthew ; Henderson, Steven ; Steffan, Janine ; Goldfarb, Audrey ; Tam, Jonathan ; Zheng, Kitty ; Cornwell, Adam ; Johnson, Adam ; Yang, Jiang Nan ; Mao, Zhiyong ; Manta, Bruno ; Dang, Weiwei ; Zhang, Zhengdong ; Vijg, Jan ; Wolfe, Aaron ; Moody, Kelsey ; Kennedy, Brian K. ; Bohmann, Dirk ; Gladyshev, Vadim N. ; Seluanov, Andrei ; Gorbunova, Vera. / SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. In: Cell. 2019 ; Vol. 177, No. 3. pp. 622-638.e22.

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10.1016/j.cell.2019.03.043