SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Xiao Tian, Denis Firsanov, Zhihui Zhang, Yang Cheng, Lingfeng Luo, Gregory Tombline, Ruiyue Tan, Matthew Simon, Steven Henderson, Janine Steffan, Audrey Goldfarb, Jonathan Tam, Kitty Zheng, Adam Cornwell, Adam Johnson, Jiang Nan Yang, Zhiyong Mao, Bruno Manta, Weiwei Dang, Zhengdong Zhang & 8 others Jan Vijg, Aaron Wolfe, Kelsey Moody, Brian K. Kennedy, Dirk Bohmann, Vadim N. Gladyshev, Andrei Seluanov, Vera Gorbunova

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

A comparative analysis of 18 rodent species identifies a role for SIRT6-dependent DNA double strand break repair as a major factor in organismal lifespan

Original languageEnglish (US)
Pages (from-to)622-638.e22
JournalCell
Volume177
Issue number3
DOIs
StatePublished - Apr 18 2019

Fingerprint

Double-Stranded DNA Breaks
Rodentia
Repair
DNA

Keywords

  • aging
  • DNA DSB repair
  • DNA repair
  • longevity
  • NER
  • SIRT6

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tian, X., Firsanov, D., Zhang, Z., Cheng, Y., Luo, L., Tombline, G., ... Gorbunova, V. (2019). SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell, 177(3), 622-638.e22. https://doi.org/10.1016/j.cell.2019.03.043

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. / Tian, Xiao; Firsanov, Denis; Zhang, Zhihui; Cheng, Yang; Luo, Lingfeng; Tombline, Gregory; Tan, Ruiyue; Simon, Matthew; Henderson, Steven; Steffan, Janine; Goldfarb, Audrey; Tam, Jonathan; Zheng, Kitty; Cornwell, Adam; Johnson, Adam; Yang, Jiang Nan; Mao, Zhiyong; Manta, Bruno; Dang, Weiwei; Zhang, Zhengdong; Vijg, Jan; Wolfe, Aaron; Moody, Kelsey; Kennedy, Brian K.; Bohmann, Dirk; Gladyshev, Vadim N.; Seluanov, Andrei; Gorbunova, Vera.

In: Cell, Vol. 177, No. 3, 18.04.2019, p. 622-638.e22.

Research output: Contribution to journal › Article

Tian, X, Firsanov, D, Zhang, Z, Cheng, Y, Luo, L, Tombline, G, Tan, R, Simon, M, Henderson, S, Steffan, J, Goldfarb, A, Tam, J, Zheng, K, Cornwell, A, Johnson, A, Yang, JN, Mao, Z, Manta, B, Dang, W, Zhang, Z, Vijg, J, Wolfe, A, Moody, K, Kennedy, BK, Bohmann, D, Gladyshev, VN, Seluanov, A & Gorbunova, V 2019, 'SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species', Cell, vol. 177, no. 3, pp. 622-638.e22. https://doi.org/10.1016/j.cell.2019.03.043
Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G et al. SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell. 2019 Apr 18;177(3):622-638.e22. https://doi.org/10.1016/j.cell.2019.03.043
Tian, Xiao ; Firsanov, Denis ; Zhang, Zhihui ; Cheng, Yang ; Luo, Lingfeng ; Tombline, Gregory ; Tan, Ruiyue ; Simon, Matthew ; Henderson, Steven ; Steffan, Janine ; Goldfarb, Audrey ; Tam, Jonathan ; Zheng, Kitty ; Cornwell, Adam ; Johnson, Adam ; Yang, Jiang Nan ; Mao, Zhiyong ; Manta, Bruno ; Dang, Weiwei ; Zhang, Zhengdong ; Vijg, Jan ; Wolfe, Aaron ; Moody, Kelsey ; Kennedy, Brian K. ; Bohmann, Dirk ; Gladyshev, Vadim N. ; Seluanov, Andrei ; Gorbunova, Vera. / SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. In: Cell. 2019 ; Vol. 177, No. 3. pp. 622-638.e22.
@article{44e198eabccd4a308aea515fa289401b,
title = "SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species",
abstract = "A comparative analysis of 18 rodent species identifies a role for SIRT6-dependent DNA double strand break repair as a major factor in organismal lifespan",
keywords = "aging, DNA DSB repair, DNA repair, longevity, NER, SIRT6",
author = "Xiao Tian and Denis Firsanov and Zhihui Zhang and Yang Cheng and Lingfeng Luo and Gregory Tombline and Ruiyue Tan and Matthew Simon and Steven Henderson and Janine Steffan and Audrey Goldfarb and Jonathan Tam and Kitty Zheng and Adam Cornwell and Adam Johnson and Yang, {Jiang Nan} and Zhiyong Mao and Bruno Manta and Weiwei Dang and Zhengdong Zhang and Jan Vijg and Aaron Wolfe and Kelsey Moody and Kennedy, {Brian K.} and Dirk Bohmann and Gladyshev, {Vadim N.} and Andrei Seluanov and Vera Gorbunova",
year = "2019",
month = "4",
day = "18",
doi = "10.1016/j.cell.2019.03.043",
language = "English (US)",
volume = "177",
pages = "622--638.e22",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

AU - Tian, Xiao

AU - Firsanov, Denis

AU - Zhang, Zhihui

AU - Cheng, Yang

AU - Luo, Lingfeng

AU - Tombline, Gregory

AU - Tan, Ruiyue

AU - Simon, Matthew

AU - Henderson, Steven

AU - Steffan, Janine

AU - Goldfarb, Audrey

AU - Tam, Jonathan

AU - Zheng, Kitty

AU - Cornwell, Adam

AU - Johnson, Adam

AU - Yang, Jiang Nan

AU - Mao, Zhiyong

AU - Manta, Bruno

AU - Dang, Weiwei

AU - Zhang, Zhengdong

AU - Vijg, Jan

AU - Wolfe, Aaron

AU - Moody, Kelsey

AU - Kennedy, Brian K.

AU - Bohmann, Dirk

AU - Gladyshev, Vadim N.

AU - Seluanov, Andrei

AU - Gorbunova, Vera

PY - 2019/4/18

Y1 - 2019/4/18

N2 - A comparative analysis of 18 rodent species identifies a role for SIRT6-dependent DNA double strand break repair as a major factor in organismal lifespan

AB - A comparative analysis of 18 rodent species identifies a role for SIRT6-dependent DNA double strand break repair as a major factor in organismal lifespan

KW - aging

KW - DNA DSB repair

KW - DNA repair

KW - longevity

KW - NER

KW - SIRT6

UR - http://www.scopus.com/inward/record.url?scp=85064151149&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064151149&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2019.03.043

DO - 10.1016/j.cell.2019.03.043

M3 - Article

VL - 177

SP - 622-638.e22

JO - Cell

JF - Cell

SN - 0092-8674

IS - 3

ER -

Access to Document