SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Xiao Tian, Denis Firsanov, Zhihui Zhang, Yang Cheng, Lingfeng Luo, Gregory Tombline, Ruiyue Tan, Matthew Simon, Steven Henderson, Janine Steffan, Audrey Goldfarb, Jonathan Tam, Kitty Zheng, Adam Cornwell, Adam Johnson, Jiang Nan Yang, Zhiyong Mao, Bruno Manta, Weiwei Dang, Zhengdong ZhangJan Vijg, Aaron Wolfe, Kelsey Moody, Brian K. Kennedy, Dirk Bohmann, Vadim N. Gladyshev, Andrei Seluanov, Vera Gorbunova

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A comparative analysis of 18 rodent species identifies a role for SIRT6-dependent DNA double strand break repair as a major factor in organismal lifespan

Original languageEnglish (US)
Pages (from-to)622-638.e22
JournalCell
Volume177
Issue number3
DOIs
StatePublished - Apr 18 2019

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Keywords

  • DNA DSB repair
  • DNA repair
  • NER
  • SIRT6
  • aging
  • longevity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tian, X., Firsanov, D., Zhang, Z., Cheng, Y., Luo, L., Tombline, G., Tan, R., Simon, M., Henderson, S., Steffan, J., Goldfarb, A., Tam, J., Zheng, K., Cornwell, A., Johnson, A., Yang, J. N., Mao, Z., Manta, B., Dang, W., ... Gorbunova, V. (2019). SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell, 177(3), 622-638.e22. https://doi.org/10.1016/j.cell.2019.03.043