Sinus histiocytosis with massive lymphadenopathy involving the orbit: Reversal of compressive optic neuropathy after chemotherapy

Sharon Goldberg, Panna Mahadevia, Michael L. Lipton, Pearl S. Rosenbaum

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A 38-year-old woman from Antigua had compressive optic neuropathy of the right eye caused by orbital involvement with sinus histiocytosis. There was also nasal sinus involvement and massive cervical lymphadenopathy resulting in radiographic compression of the airway and carotid sheath. Because of the compressive optic neuropathy and threat to the airway and carotid perfusion, the patient underwent a 6-month chemothera-pcutic regimen of cyclophosphamide, vincristine, and prednisone. After chemotherapy, the visual dysfunction resolved in correlation with diminution of the orbital mass, and marked regression of the cervical lymphadenopathy. This case demonstrates the potential efficacy of chemotherapy in the treatment of compressive oplic neuropathy in cases of orbital sinus histiocytosis with massive lymphadenopathy.

Original languageEnglish (US)
Pages (from-to)270-275
Number of pages6
JournalJournal of Neuro-Ophthalmology
Volume18
Issue number4
StatePublished - 1998

Fingerprint

Sinus Histiocytosis
Optic Nerve Diseases
Orbit
Antigua and Barbuda
Drug Therapy
Paranasal Sinuses
Vincristine
Prednisone
Cyclophosphamide
Perfusion
Lymphadenopathy
Therapeutics

Keywords

  • Chemotherapy
  • Optic neuropathy
  • Rosai-Dorfman disease
  • Sinus histocytosis with massive lymphadenopathy

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

Cite this

Sinus histiocytosis with massive lymphadenopathy involving the orbit : Reversal of compressive optic neuropathy after chemotherapy. / Goldberg, Sharon; Mahadevia, Panna; Lipton, Michael L.; Rosenbaum, Pearl S.

In: Journal of Neuro-Ophthalmology, Vol. 18, No. 4, 1998, p. 270-275.

Research output: Contribution to journalArticle

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