Single-nucleotide polymorphisms in TrkB and risk for depression: Findings from the women's interagency HIV study

Valeriya Avdoshina, Italo Mocchetti, Chenglong Liu, Mary A. Young, Kathryn Anastos, Mardge Cohen, Howard Crystal, Celeste L. Pearce, Elizabeth T. Golub, Rochelle E. Tractenberg

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Individuals infected with HIV type 1 are more likely than noninfected individuals to develop depression. HIV lowers brain-derived neurotrophic factor (BDNF), a neurotrophic factor whose receptors play a crucial role in the pathophysiology of depression. Therefore, we examined whether a single-nucleotide polymorphism in the BDNF gene (rs56164415) and related receptors TrkB (rs1212171) and p75 (rs2072446) were associated with depression in HIV-infected individuals. A total of 1365 HIV-positive and 371 HIV-negative female subjects were included. The distribution of alleles was analyzed independently in African Americans (non-Hispanic) and Caucasians (non-Hispanic). We have found that the absence of depressive symptoms in HIV-positive subjects is associated with a genetic variation of the TrkB but not with BDNF or p75 genes. This mutation explains 0.8% and 4.4% of the variability for the absence of depression in African Americans and Caucasians, respectively.

Original languageEnglish (US)
Pages (from-to)138-141
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume64
Issue number2
DOIs
StatePublished - Oct 1 2013

Keywords

  • Association studies
  • BDNF
  • HIV-1
  • p75NTR
  • rs1212171
  • rs2072446

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Single-nucleotide polymorphisms in TrkB and risk for depression: Findings from the women's interagency HIV study'. Together they form a unique fingerprint.

  • Cite this

    Avdoshina, V., Mocchetti, I., Liu, C., Young, M. A., Anastos, K., Cohen, M., Crystal, H., Pearce, C. L., Golub, E. T., & Tractenberg, R. E. (2013). Single-nucleotide polymorphisms in TrkB and risk for depression: Findings from the women's interagency HIV study. Journal of Acquired Immune Deficiency Syndromes, 64(2), 138-141. https://doi.org/10.1097/QAI.0b013e3182a468e9